英文名称： Cilnidipine (FRC-8653)
Cilnidipine (FRC-8653)，≥98%
【英文同义名】：FRC-8653,Atelec®, Cilaheart®, Cilacar®
【中文同义名】：西尼地平
订购信息：（原装进口，常备现货）
| 品 牌 | 产品名称 | 产品货号 | 规 格 | 目录价（元） |
| Gene Operation | Cilnidipine (FRC-8653) | IIC1158-0010MG | 10 mg | ¥529.00 |
| IIC1158-0050MG | 50 mg | ¥1,849.00 |
产品描述
Cilnidipine(西尼地平，又称为FRC-8653)是一种独特的钙离子通路拮抗剂，具有缓发但持久的血管舒张和抗高血压活性[1]。 Cilnidipine强效抑制大鼠背根神经节神经元中N-型和L-型电压依赖型钙通道[2]。Cilnidipine 还抑制大鼠A7r5细胞中钙流，IC50为10 nM，并抑制大鼠主动脉环中去极化和Ca2+诱导的收缩反应[3]。在自发性高血压大鼠(SHRs)中，cilnidipine显著抑制急性冷应激诱导的升压反应，并降低冷应激诱导的血液中去甲***的提高[4]。另外，cilnidipine可以减小局灶性脑缺血大鼠的脑梗塞面积[5]，降低NMDA诱导的视网膜损伤[6]。
Cilnidipine是一种新型钙离子通路阻断剂，在1995年已被批准用于高血压的治疗。以Atelec，Cilacar，LNBLOC和CILAHEART (Mankind)的名称分别在日本和印度上市。
靶点
| Targets | calcium channels |
| IC50 | 1 nM |
化学特性
| Cas No.: 132203-70-4 | M. Wt.: 492.52 |
| Formula: C27H28N2O7 | Purity: ≥98% |
Synonym: FRC-8653,Atelec®, Cilaheart®, Cilacar® | |
| Chemical Name: 3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate | |
Appearance: Yellow crystalline solid | |
| Solubility: Soluble in DMSO (> 25 mg/ml), ethanol (20 mg/ml), water (≤ 2 mg/ml) | |
| Storage：Store solid at -20 ºC for the stability of two years. | |
结构式
参考文献
[1] Oike M. et al. Dual action of FRC8653, a novel dihydropyridine derivative, on the Ba2+ current recorded from the rabbit basilar artery. Circ Res. 67(4):993-1006(1990).
[2] Hisayuki Uneyama.et al. Blockade of N-type Ca2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones.British Journal of Pharmacology.122 (1) :37–42( 1997).
[3] Akira Takahara. Cilnidipine: A New Generation Ca2+ Channel Blocker with Inhibitory Action on Sympathetic Neurotransmitter Release. Cardiovasc Ther. 27(2):124-39 (2009).