gene operationBrand,null 产品货号： ICC1113-0001MGItem#, Roscovitine / Seliciclib<br>英文名称： Roscovitine / Seliciclib

Roscovitine / Seliciclib，>98%

【英文同义名】：Seliciclib, CYC202

【中文同义名】：

订购信息：（原装进口，常备现货）

品牌	产品名称	产品货号	规格	目录价（元）
Gene Operation	Roscovitine / Seliciclib	ICC1113-0001MG	1 mg	¥519.00
		ICC1113-0010MG	10 mg	¥1,199.00
		ICC1113-0050MG	50 mg	¥3,699.00

产品描述

Roscovitine是一种强效的选择性cdk抑制剂，抑制cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E和cdk5/p53，IC₅₀分别为0.65，0.7，0.7和0.16 μM。Roscovitine抑制非洲爪蟾卵提取物中M期促进因子活性和体外DNA合成，可以抑制***诱导的卵母细胞突变，并抑制体内延伸因子eEF-1***酸化^[1]。Roscovitine抑制体内外系膜细胞(MC) ^[2]和ESFT^[3]的增殖，有效地诱导体外和移植瘤中肿瘤细胞凋亡。另外，Roscovitine还是一种抗病毒药物，引起HIV感染的细胞死亡，阻止疱疹单纯病毒的复制。Roscovitine已经用于NSCLC，白血病，HIV感染，单纯疱疹感染和囊性纤维化的临床实验中。

靶点

Targets	cdc2/cyclin B	cdk2/cyclin A	cdk2/cyclin E	cdk5/p35
IC₅₀	0.65 μM	0.7 μM	0.7 μM	0.2 μM

化学特性

Cas No.: 186692-46-6	M. Wt.: 354.45
Formula: C₁₉H₂₆N₆O	Purity: >98%
Synonym: Seliciclib, CYC202
Chemical Name: (R)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol
Appearance: solid
Solubility: Soluble in DMSO (150 mM)
Storage：Store solid at -20 ºC for the stability of three years.

结构式

参考文献

[1] Meijer L.et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem. 243(1-2):527-36 (1997).

[2] Pippin JW.et al. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. J Clin Invest.100(10):2512-20.(1997).

Synonym: Seliciclib, CYC202

Appearance: solid