KB-R7943 Mesylate 英文名称: KB-R7943 Mesylate | |||||||||||||||||||||||||||||||||||||||
型号:null 产品货号: IIC1051-0010MG | |||||||||||||||||||||||||||||||||||||||
价格:请致电:010-57128832,18610462672 | |||||||||||||||||||||||||||||||||||||||
品牌: gene operation | |||||||||||||||||||||||||||||||||||||||
IIC1051 KB-R7943 Mesylate(中文网页版) KB-R7943 Mesylate,>99% 【英文同义名】:KB-R7943; KB-R 7943 【中文同义名】:KB-R7943 甲磺酰酸盐 订购信息:(原装进口,常备现货)
产品描述KB-R7943甲磺酸盐(KB)是选择性的Na+/Ca2+ 交换器(NCX)抑制剂 (IC50 = 0.7 μM)[1],并抑制ouabain的嗜张力性作用,因此,在麻醉豚鼠中用于诱导室性早搏(VPB)、室性心动过速(VT)、心室纤颤(VF)和心脏骤停(CA)需要的ouabain剂量增加,而且KB-R7943甲磺酸盐可以延长离体心房中ouabain 诱导的额外收缩的发作时间[2]。KB-R7943甲磺酸盐还可以抑制K+依赖的Na+/Ca2+交换器(NCKX) [3]和线粒体Ca2+单向转运体(MCU) (IC50 = 5.5 μM) [4]。另外,KB-R7943甲磺酸盐抑制钠离子门控通路(SGC),并降低通路开放几率而不影响单通道振幅[5]。 靶点
化学特性
储存液配制
结构式使用浓度(仅作参考)KB-R7943 Mesylate的具体使用浓度请参考相关文献,并根据自身实验条件(如实验目的,细胞种类,培养特性等)进行摸索和优化。 参考文献[1] Hoyt KR. et al. Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons. Mol Pharmacol. 53(4):742-9(1998). [2] Watano, T., et al. Effect of Na+/Ca2+ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs. Br. J. Pharmacol. 127: 1846-1850(1999). [3] Su, Y.H., et al. A flagellar K+-dependent Na+/Ca2+ exchanger keeps Ca2+ low in sea urchin spermatozoa. PNAS 99(10): 6743-6748(2002). [4] Santo-Domingo, J., et al. The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter. Br. J. Pharmacol. 151: 647-654(2007). [5] Pezier, A., et al. The Na+/Ca2+ Exchanger Inhibitor, KB-R7943, Blocks a Nonselective Cation Channel Implicated in Chemosensory Transduction. J Neurophysiol 101(3): 1151-1159 (2009). |