英文名称： Mifepristone
IHR1201-Mifepristone（中文网页版）
Mifepristone，≥98%
【英文同义名】：米非司***
【英文同义名】：RU-486, RU 38486, Mifeprex®, Korlym®, RU486, C-1073
订购信息：（原装进口，常备现货）
| 品 牌 | 产品名称 | 产品货号 | 规 格 | 目录价（元） |
| Gene Operation | Mifepristone | IHR1201-0100MG | 100 mg | ¥1,279.00 |
| IHR1201-0500MG | 500 mg | ¥4,039.00 |
产品描述
Mifepristone（米非司***）是一种强有效的孕***和糖皮质***受体拮抗剂，其IC50分别为0.2nM and 2.6nM [1]。Mifepristone可阻止DNA合成，使细胞周期停滞在G1-S期，并以剂量依赖的方式抑制体内外人上皮性卵巢癌细胞和脑膜瘤细胞生长[2]。Mifepristone还可以抑制正常的及恶性的子宫内膜细胞、前列腺癌细胞[3]和胃癌细胞[4]增殖。另外，mifepristone显著提高阿尔茨海默（Alzheimer’s disease (AD)）病人的皮质醇水平[5]。最近一项研究表明，mifepristone可诱导无论分化或未分化的表达caspase-1的胚胎干细胞的caspase-1的表达[6]。
靶点
| 靶点 | Progesterone receptor | Glucocorticoid receptor |
| IC50（半数有效浓度） | 0.2 nM | 2.6 nM |
化学特性
| Cas No.: 84371-65-3 | M. Wt.: 429.6 |
| Formula: C29H35NO2 | Purity: ≥98% |
Synonym: RU-486, RU 38486, Mifeprex®, Korlym®, RU486, C-1073 | |
| Chemical Name: 11β-(4-Dimethyl-amino)-phenyl-17β-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one | |
Appearance: White to Light yellowish powder | |
| Solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming | |
| Storage：Store powder at -20 ºC for the stability of two years | |
储存液配制
| 储存液 (1 ml DMSO体系) | 5mM | 7mM | 10mM |
| 质量(mg) | 2.148 | 3.0072 | 4.296 |
结构式
使用浓度(仅作参考)
Mifepristone的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。
参考文献
[1] Weiqin Jiang, George Allan, James J et al. New progesterone receptor antagonists: Phosphorus-containing 11b-aryl-substituted steroids. Bioorganic & Medicinal Chemistry. 14: 6726–6732 (2006).
[2] Alicia, A., et al. Mifepristone Inhibits Ovarian Cancer Cell Growth In vitro and In vivo. Clin Cancer Res 13: 3370-3379(2007).
[3] El Etreby, M.F., et al. Antitumor activity of mifepristone in the human LNCaP, LNCaP-C4, and LNCaP-C4-2 prostate cancer models in nude mice. Prostate 42: 99-106(2000).
[4] Li, D.Q., et al. Effects of mifepristone on proliferation of human gastric adenocarcinoma cell line SGC-7901 in vitro.World J Gastroenterol 10: 2628-2631(2004).
[5] Pomara, N., et al. The Effect of Mifepristone (RU 486) on Plasma Cortisol in Alzheimer’s Disease. Neurochemical Research 31(5): 585-588(2006).
[6] YI WANG,DEHUAYANG,LIN SONG, et al. Mifepristone-Inducible Caspase-1 Expression in Mouse Embryonic Stem Cells Eliminates Tumor Formation but Spares Differentiated Cells In Vitro and In Vivo. Stem cells. 30(2):169-79(2012)