IEN1003- Okadaic Acid, Sodium Salt

【英文同义名】：Halochondrine A, sodium salt

【中文同义名】：软海绵酸钠盐, 冈田酸钠盐，黑海棉酸钠盐

订购信息：（原装进口，常备现货）

品牌	产品名称	产品货号	规格	目录价（元）
Gene Operation	Okadaic Acid, Sodium Salt	IEN1003-0050UG	50UG	¥979.00
		IEN1003-0100UG	100UG	¥1,599.00
		IEN1003-1000UG	1000UG	¥12,029.00

产品描述

冈田酸钠盐是冈田酸游离酸的一种盐形式。它们有相同的生物活性，但是在有机溶剂中盐形式比游离酸形式要更加的稳定。

冈田酸（简称为OA），是一种非佛波型肿瘤启动子^[1]，并且是丝氨酸/苏氨酸蛋***酸酶（PP）1（IC ₅₀=15～20nM）和2A（IC ₅₀= 0.1 nM）的强效和选择性抑制剂。冈田酸对PP2B的抑制效果没有对PP1的强，对PP2C则没有任何抑制效果。由于冈田酸不影响酪氨酸***酸酶，碱性***酸酶和酸性***酸酶的活性。所以它是研究***酸化控制细胞过程的非常有用的工具^[2-3]。冈田酸对平滑肌和心脏肌具有收缩作用^[4]，能诱导人成骨细胞（Saos-2，MG63）^[5]，人乳腺癌细胞（MB-231，MCF7）^[6]和髓样细胞的凋亡，但是在T细胞杂交瘤中它能抑制糖皮质***诱导的细胞凋亡^[7]。

靶点

Targets	PP1	PP2A
Ki	15-20 nM	0.1 nM

化学特性

Cas No.: 209266-80-8	分子量: 826.98
分子式: C₄₄H₆₇O₁₃Na	纯度: >98%
同义名: Halochondrine A, sodium salt
化学名: 9,10-Deepithio-9,10-didehydroacanthifolicin, sodium salt
外观: White solid or clear, colorless solid film
溶解度: Soluble in DMSO or ethanol
保存：Store solid at -20 ºC for the stability of two years. Aliquot the stock solution and freeze at -20 ºC for the stability up to one month, preventing from multiple freeze/thaw cycles.

储存液配制

储存液 (1 ml DMSO体系)	1 mM	5 mM	10 mM	25 mM	50 mM
质量(mg)	0.82698	4.1349	8.2698	20.6745	41.349

结构式

使用浓度(仅作参考)

Okadaic Acid, Sodium Salt的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。

参考文献

[1] Suganuma M, et al. Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetat- type tumor promoter. Proc Natl Acad Sci U S A. 85(6): 1768–71 (1988).

[2] Bialojan C, et al. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phospha- teases. Specificity and kinetics. Biochem J. 256(1):283-90 (1988).

[3] Cohen P, et al. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci. 15(3):98-102 (1990).

[4] Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.

Biochem. Biophys. Res. Comm. 159: 871-7 (1989).

[5] Morimoto Y, et al. The Protein Phosphatase Inhibitors Okadaic Acid and Calyculin A Induce Apoptosis in Human Osteoblastic Cells. Experimental Cell Research, 230(2):181-6 (1997).

[6] Kiguchi K, et al. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Cell Growth Differ. 5(9):995-1004 (1994).

[7] Ohoka Y, et al. Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage. Biochem Biophys Res Commun. 197(2):916-21 (1993).

同义名: Halochondrine A, sodium salt