THIOLUTIN
英文名称： THIOLUTIN
型号:null    产品货号： T3450
价格:请致电：010-57128832,18610462672
品牌: 进口(美国)

SAP货号(带包装):T3450-1MG
货号：T3450
品牌：SIGMA
英文品名(部分):THIOLUTIN
完整英文品名:Thiolutin >=95% (HPLC)
Sigma产品分类描述:CELL SIGNALLING, SMALL MOLECULES, OTHER
CAS编号:87-11-6
MDL Number:MFCD07370147
产品在Sigma网站链接:http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=T3450|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC

">【英文同义名】：Fluoxetine HCl, LY110140HCl, LY110140HCl, LY110140 hydrochloride,

LY-110,140HCl, Prozac®, Sarafem®, Ladose®andFontex® 

【中文同义名】：盐酸氟西汀

订购信息：（原装进口，常备现货）

品  牌

产品名称

产品货号

规 格

目录价（元）

Gene Operation

Fluoxetine hydrochloride

INS1005-0025MG

25 mg

¥569.00

INS1005-0100MG

100 mg

¥1,719.00

产品描述

Fluoxetine hydrochloride (同义名: Fluoxetine HCl, LY110140HCl, LY110140HCl, LY110140 hydrochloride, LY-110,140HCl, Prozac®, Sarafem®, Ladose®andFontex®) ，氟西汀游离碱的盐酸盐形式是一种非常强效的选择性血清素再吸收的抑制剂[1-2]，而且作为临床有用的抗抑郁药，机理是通过增加与神经传递相关的血清素含量发挥作用[3]。氟西汀可以与人的5-HT转运体结合(Ki值为0.9-20 nM)，其选择性结合效率比5-HT1A，5-HT 2A，H 1，α1，α2-***能和毒蕈碱受体高约150-900倍[4]。，它一般作为Prozac®，Sarafem®，Ladose®和Fontex®品牌销售药品的活性成分，对重度抑郁症，强迫性神经症，神经性贪食症，恐慌症和经前烦躁症的具有疗效。

 

靶点

靶点

 

IC50（半数有效浓度）

 

化学特性

Cas No.:56296-78-7

分子量:345.79

分子式:C17H18F3NO·HCl

纯度:≥98% 

同义名:Fluoxetine HCl, LY110140HCl, LY110140HCl, LY110140 hydrochloride, LY-110,140HCl, Prozac®, Sarafem®, Ladose®andFontex® 

化学名：3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamineHCl, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride

外观:白色至类白色粉末

溶解: 溶于DMSO(up to 69 mg/mL)

保存：3年-20℃粉末

储存液配制

储存液 (1 ml DMSO体系)

1 mM

5mM

10mM

25mM

50mM

100mM

质量(mg)

0.3457

1.7290

3.4579

8.6448

17.2895

34.5790

结构式

使用浓度(仅作参考)

Fluoxetine hydrochloride的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。

参考文献

[1] Wong DT, et al. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethyl- phenoxy)-N-methyl-3-phenylpropylamine. Life Sci. 15(3):471-9 (1974).

[2] Fuller RW, et al. Fluoxetine, a selective inhibitor of serotonin uptake. Med Res Rev.11(1):

17-34 (1991).

[3] Benfield P, et al. Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties,and therapeutic efficacy in depressive illness. Drugs. 32(6):481-508 (1986).

[4] Owens MJ, et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.J PharmacolExpTher. 283(3):1305-22 (1997).

[5] Chang EA, et al. Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells. Int J Dev Biol. 54(4):707-15 (2010). 

rial",sans-serif;font-weight:normal;mso-bidi-font-weight:bold">(仅作参考)

Fulvestrant的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。

参考文献

[1] Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 51(15):3867-73 (1991).

[2] de Cupis A, et al. Comparison between novel steroid-like and conventional nonsteroidal antioestrogens in inhibiting oestradiol- and IGF-I-induced proliferation of human breast cancer-derived cells. Br J Pharmacol. 116(5): 2391–2400 (1995).

[3] Howell, et al. ICI 182,780 (FaslodexTM): Development of a novel, "pure" antiestrogen. Cancer 89: 817-825(2000).

[4] Thomas P, et al. Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells. Endocrinology. 146(2):624-32 (2005).

[5] Zhao L, et al. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. J Pharmacol Exp Ther. 319(3):1124-32 (2006).