Xamoterol hemifumarate
英文名称: Xamoterol hemifumarate
型号:null    产品货号: IHR1061-0010MG
价格:请致电:010-57128832,18610462672
品牌: gene operation

 IHR1061-Xamoterol hemifumarate

Xamoterol hemifumarate≥97%

【英文同义名】:Xamoterol ;Corwin; Xamoterol fumarate (USAN);

【中文同义名】:

订购信息(原装进口,常备现货)

 

产品名称

产品货号

规 格

目录价(元)

Gene Operation

Xamoterol hemifumarate(ICI 118,587)

(β1-adrenoceptor-selective partial agonist)

IHR1061-0010MG

10MG

¥2,179.00

Gene Operation

IHR1061-0050MG

50MG

¥9,099.00

产品描述

Xamoterol hemifumarate(同义名:  Xamoterol ;Corwin; Xamoterol fumarate (USAN)) 是一种***有效的,竞争性和选择性β1***受体激动剂,在透壁性刺激的豚鼠回肠中以浓度依赖方式抑制收缩,并在卡巴胆碱刺激的豚鼠气管和孕***预处理的雌性大鼠中表现出松弛作用[1]Xamoterol hemifumarate在乳头肌和自发跳动的右心房中分别具有正性肌力作用和正性变时作用,并显著提高cAMP水平[2]。服用xamoterol hemifumarate可提高脂肪前体细胞的数量[3]。另外,xamoterol hemifumarate可提高心率,其作用方式为剂量依赖型[4]

靶点

靶点

β1- adrenoceptor

IC50(半数有效浓度)

 

化学特性

Cas No.: 73210-73-8

分子量: 397.43

分子式: C16H25N3O5· 0.5C4H4O4

纯度: ≥97% 

同义名: Xamoterol ;Corwin; Xamoterol fumarate (USAN);

化学名:1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate

外观: 类白色固体

溶解: 溶于DMSO(up to 100 mg/mL)

保存:3 -20 固体

储存液配制

储存液 (1 ml DMSO体系)

1 mM

5 mM

10 mM

25 mM

50 mM

100 mM

质量(mg)

0.3974

1.9872

3.9743

9.9358

19.8715

39.7430

结构式

使用浓度(仅作参考)

Xamoterol hemifumarate的具体使用浓度请参考相关文献,并根据自身实验条件(如实验目的,细胞种类,培养特性等)进行摸索和优化。

参考文献

[1] Malta, E., et al. The in vitro pharmacology of xamoterol (ICI 118,587). Br. J. Pharmacol. 85: 179-187(1985).

[2] Hattori, Y., et al. Pharmacological analysis of the cardiac actions of xamoterol, a beta adrenoceptor antagonist with partial agonistic activity, in guinea pig heart: evidence for involvement of adenylate cyclase system in its cardiac stimulant actions. JPET 242(3): 1077- 1085(1987).

[3] Barbatelli, G., et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am. J. Physiol Endocrinol Metab 298: E1244–E1253(2010).

[4] Zelaszczyk, D., et al. Four close bupranolol analogues are antagonists at the low-affinity state of ß1-adrenoceptors. Journal of Physiology And Pharmacology, 60: 51–60(2009).