英文名称： Okadaic Acid, Potassium
IEN1004-Okadaic Acid, Potassium
Okadaic Acid, Potassium，>98%
【英文同义名】：Halochondrine A, potassium salt
【中文同义名】：冈田酸钾盐
订购信息：（原装进口，常备现货）
| 品 牌 | 产品名称 | 产品货号 | 规 格 | 目录价（元） |
| Gene Operation | Okadaic Acid, Potassium | IEN1004-0050UG | 50 UG | ¥979.00 |
| IEN1004-0100UG | 100UG | ¥1,599.00 | ||
| IEN1004-1000UG | 1000 UG | ¥12,029.00 |
产品描述
Okadaic Acid, Potassium 是Okadaic acid(OA)的钾盐形式,是一种非佛波醇型肿瘤促进剂 [1]，可以抑制PP1和PP2A的活性，其IC50 分别为15-20 nM和0.1 nM。与PP1相比,Okadaic acid对PP2B的活性较低，对PP2C无抑制效果。Okadaic acid不影响酪氨酸***酸酶，碱性***酸酶，酸性***酸酶的活性，是研究细胞内***酸化过程的有力工具[2-3]。同时，okadaic acid可以诱导平滑肌纤维收缩[4。Okadaic acid还能诱导人成骨细胞（Saos-2，MG63）[5]、人乳腺癌细胞（MB-231，MCF7）[6]和骨髓细胞的凋亡，但能抑制糖皮质***诱导T细胞杂交瘤细胞凋亡[7]。相比于游离酸，冈田酸钾盐在有机溶剂中有更高的稳定性。
靶点
| 靶点 | PP1 | PP2A |
| IC50（半数有效浓度） | 15-20 nM [1] | 0.1 nM [1] |
化学特性
| Cas No.: 155751-72-7 | 分子量: 843.09 |
| 分子式: C44H67O13K | 纯度: >98% |
| 同义名: Halochondrine A, potassium salt | |
| 化学名: 9,10-Deepithio-9,10-didehydroacanthifolicin, potassium salt | |
| 外观: White solid or clear, colorless solid film | |
| 溶解: 溶于DMSO | |
| 保存：：2年 -20℃粉状 | |
储存液配制
| 储存液 (1 ml DMSO体系) | 1 mM | 5 mM | 10 mM | 25 mM | 50 mM | 100 mM |
| 质量(mg) | 0.8431 | 4.2155 | 8.4309 | 21.0773 | 42.1545 | 84.3090 |
结构式
使用浓度(仅作参考)
Okadaic Acid, Potassium的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。
参考文献
[1] Suganuma M, et al. Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetat- type tumor promoter. Proc Natl Acad Sci U S A. 85(6): 1768–71 (1988).
[2] Bialojan C, et al. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phospha- teases. Specificity and kinetics. Biochem J. 256(1):283-90 (1988).
[3] Cohen P, et al. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci. 15(3):98-102 (1990).
[4] Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
Biochem. Biophys. Res. Comm. 159: 871-7 (1989).
[5] Morimoto Y, et al. The Protein Phosphatase Inhibitors Okadaic Acid and Calyculin A Induce Apoptosis in Human Osteoblastic Cells. Experimental Cell Research, 230(2):181-6 (1997).
[6] Kiguchi K, et al. Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Cell Growth Differ. 5(9):995-1004 (1994).
[7] Ohoka Y, et al. Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage. Biochem Biophys Res Commun. 197(2):916-21 (1993).