肝素 英文名称: HEP |
型号:null 产品货号: 0863 |
价格:请致电:010-57128832,18610462672 |
品牌: 美国sciencell |
北京裕恒丰科技有限公司,已成功代理美国Sciencell公司细胞生物学产品十余年。多年来,裕恒丰一直秉承信誉至上的原则,在点滴中慢慢地提升企业信誉,树立企业形象,我们始终以热心的服务和专业的技术支持,为广大科研工作者提供了优质的细胞及分子生物学产品。在未来的发展中,我们将继续努力打造企业品牌,北京裕恒丰不仅希望您能聆听到我们的心声,更期待您能亲自体验我们的服务,北京裕恒丰欢迎您的光临。 温馨提示:ScienCell产品仅用于科研,不能用于人或动物以及体外诊断应用。如预购买产品请登陆ScienCell唯一官网(www.sciencellonline.com)寻找正规代理商,以确保您的实验顺利进行。 肝素 货号0863 产品介绍 Heparin is a 10-12 kDa polysaccharide produced in mast cells. Heparin inhibits blood coagulation through binding and activation of anti-thrombin [1] and acts as a cofactor to basic Fibroblast Growth Factor-2 (bFGF) [2, 3, 4]. The effect of heparin on cell growth and morphology in vitro is cell-type dependent and may promote or inhibit cell proliferation. Culture media may be supplemented with heparin solution (HEP) at 1:1000-1:100 (0.4 – 4.0 U/mL). The optimal concentration should be determined for individual cell types and culture conditions. 参考文献 [1] Bjork I and Lindahl U. (1982) “Mechanism of the anticoagulant action of heparin”. Mol Cell Biochem, 48(3):161-82. [2] Rapraeger AC, Krufka A and Olwin BB. (1991) “Requirement of heparin sulfate for bFGF-mediated fibroflast growth and myoblast differentiation”. Science. 252(5013):1705-8. [3] Roghani M, Mansukhani A, et al. (1994) “Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding”. J Biol Chem. 269(6):3976-84. [4] Sasisekharan R, Ernst S and Venkataraman G. (1997) “On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans”. Angiogenesis, 1(1):45-54. Caution: If handled improperly, some components of this product may present a health hazard. Take appropriate precautions when handling this product, including the wearing of protective clothing and eyewear. Dispose of properly.
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