英文名称： HCF
产品名称：人心脏成纤维细胞
英文名称：Human Cardiac Fibroblasts
货号：6300
品牌：ScienCell
产地：美国
规格：5 x10^5，1ml
价格：$614
产品说明 使用说明 储存 运输 文献1.) Chida J, Araki H, Maeda Y. (2014) "Specific growth suppression of human cancer cells by targeted delivery of Dictyostelium mitochondrial ribosomal protein S4." Cancer cell int. 14: 56.
CF是心肌损伤反应的重要细胞成分和旁分泌生长因子的来源。CF的增殖和基质合成对于心肌梗塞、心肌纤维化部位瘢痕形成具有重要作用。CF的培养已被广泛应用为生理（运动）和病理（高血压）应激下心脏基质重塑研究的模型。
Sciencell研究实验室的HCF是从人心脏分离得到的，原代冻存，冰冻运输。每管细胞密度超过5×10^5/ml。细胞特性经纤维粘连蛋白免疫荧光鉴定。本细胞经检测不含HIV-1、HBV、HCV、支原体、细菌、酵母菌和真菌。如采用ScienCell 实验室特制的培养基，可保证此细胞15倍增增殖。
推荐培养基
成纤维细胞培养基-2（货号：2331 ）
人心脏成纤维细胞仅用于科研。不能用于人或动物和体外诊断应用。
接收到冻存细胞时请立即从干冰转入液氮中保存。
干冰运输。
2.) Huntley BK, Ichiki T, Sangaralingham SJ, Chen HH, Burnett JC Jr. (2010) "B-type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts." J Cell Physiol. 225: 251-5.
3.) Lin CS, Pan CH, Wen CH, Yang TH, Kuan TC. (2010) "Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts." Peptides. 31: 1334-40.
4.) Westenbrink BD, Ruifrok WP, Voors AA, Tilton RG, van Veldhuisen DJ, Schoemaker RG, van Gilst WH, de Boer RA. (2010) "Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure." Cardiovasc Res. 87: 30-9.
5.) Huntley BK, Ichiki T, Sangaralingham SJ, Chen HH, Burnett JC. (2010) "B?type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts." J of cell physiol. 225: 251-55.
6.) McKie PM, Cataliotti A, Huntley BK, Martin FL, Olson TM, Burnett JC Jr. (2009) "A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions." J Am Coll Cardiol. 54: 1024-32.
7.) Lisy O, Huntley BK, McCormick DJ, Kurlansky PA, Burnett JC Jr. (2008) "Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP." J Am Coll Cardiol. 52: 60-8.
8.) Pan CH, Wen CH, Lin CS. (2008) "Interplay of angiotensin II and angiotensin(1-7) in the regulation of matrix metalloproteinases of human cardiocytes." Exp Physiol. 93: 599-612.
9.) Reddy VS, Harskamp RE, van Ginkel MW, Calhoon J, Baisden CE, Kim IS, Valente AJ, Chandrasekar B. (2008) "Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation." J Cell Physiol. 215: 697-707.
10.) Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D. (2008) "Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction." Circulation. 117: 2224-31.
11.) Bunda S, Liu P, Wang Y, Liu K, Hinek A. (2007) "Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner." Am J Pathol. 171: 809-19.
12.) Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B. (2007) "IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation." Am J Physiol Heart Circ Physiol. 293: H3356-65.
13.) Noser JA, Mael AA, Sakuma R, Ohmine S, Marcato P, Lee PW, Ikeda Y. (2007) "The RAS/Raf1/MEK/ERK Signaling Pathway Facilitates VSV-mediated Oncolysis: Impli cation for the Defective Interferon Response in Cancer Cells." Mol Ther. 15: 1531-6.
14.) Huntley BK, Sandberg SM, Noser JA, Cataliotti A, Redfield MM, Matsuda Y, Burnett JC Jr. (2006) "BNP-induced activation of cGMP in human cardiac fibroblasts: Interactions with fibronectin and natriuretic peptide receptors." J Cell Physiol. 209: 943-9.
