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Transforming Growth Factor beta-1 ( TGF-beta1 / TGFB1 ) Protein
 
 
 
TGF-beta1 / TGFB1 Protein Price Inquiry ( Available Sizes )
 
 
 
200 μg:  询价;
 
500 μg:  询价;
 
≥1mg 大包装:  询价
 
 
 
TGF-beta1 / TGFB1蛋白产品信息
 
 
 
 
Synonym:
 
 
CED  ,  DPD1 ,  LAP ,  TGFB ,  TGFbeta , TGFB1
 
 
 
 
表达方式:
 
 
A DNA sequence encoding the active form of human TGFβ1 ( NP_000651.3 ) ( Ala 279 - Ser 390 ) was expressed and purified
 
 
 
 
种属:
 
Human   
 
 
 
表达宿主: 
 
Human Cells
 
 
 
 
TGF-beta1 / TGFB1 Protein QC Testing
 
 
 
 
纯度:
 
> 95 % as determined by SDS-PAGE
 
SDS-PAGE:
 
 
TGF-beta1 protein
 
 
 
 
 
生物活性:
 
 
 
Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells.
 The ED50 for this effect is typically  0.04 - 0.2  ng/ml 
 
 
 
 
内毒素:
 
0.15 EU / mg  protein as determined by the LAL method
 
 
 
稳定性:
 
Samples are stable for up to twelve months from date of receipt at -70℃
 
 
 
预测N端:
 
Ala 279
 
 
 
分子量:
 
 
The recombinant human TGFβ1 consists of 112 amino acids and has a calculated molecular mass of 12.8 kDa. rh TGFβ1 migrates as an approximately 13 & 26 kDa band in reduced and non-reduced SDS-PAGE respectively, corresponding to the monomer and homodimer
 
 
 
 
缓冲液:
 
 
Lyophilized from sterile 0.1% TFA , 40% acetonitrile , 1% isopropanol
 
 
 
 
 
TGF-beta1 / TGFB1 Protein Usage Guide
 
 
 
 
储存方法:
 
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
 
 
 
 
 
Reconstitution:
 
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
 
 
 
 
TGF-beta1 / TGFB1 Protein Related Products & Topics
 
 
TGF-beta1 / TGFB1 Antibody 相关研究领域:
 
Neuroscience>>Axon Guidance>>TGF-beta Family>>TGF-beta 1
 
Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>>TGF-beta 1
 
Cancer>>Cancer Biomarkers>>TGF-beta 1
 
Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGF-beta 1
 
Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>TGF-beta 1
 
Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>TGF-beta 1
 
蛋白:
 
 
 
 
Molecule
 
Species
 
Description //For Detailed Info.------CLICK!
 
Cat No
 
 
 
TGF-beta 1
 
Human
 
Latent TGF-beta 1 protein, Recombinant 
 
10804-H08H
 
 
 
TGF-beta 1
 
Human
 
TGF-beta 1 Protein, Recombinant
 
10804-HNAH
 
 
 
 
抗体:
 
 
 
 
Molecule
 
Application
 
Description //For Detailed Info.------CLICK!
 
Cat No
 
 
 
Human 
 TGF-beta 1
 
WB
 
Mouse Monoclonal Antibody
 
10804-MM03
 
 
 
Human 
 TGF-beta 1
 
ELISA
 
Mouse Monoclonal Antibody
 
10804-MM06
 
 
 
Human 
 TGF-beta 1
 
WB, ELISA
 
Rabbit Polyclonal Antibody
 
10804-RP01
 
 
 
Human 
 TGF-beta 1
 
WB, ELISA
 
Rabbit Polyclonal Antibody (Antigen Affinity Purified)
 
10804-RP02
 
 
 
 
 
TGF-beta1 / TGFB1蛋白背景综述
 
 
Transforming growth factor beta 1 (TGFβ1) is a member of the large transforming growth factor beta superfamily of cytokines, and serves as a multifunctional molecule performing actions in many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. TGFβ1 was first synthesized as a 390 amino acid precusor. The secreted proprotein contains 360 aa, and is cleaved into mature TGFβ1 (112 aa) and latency-associated peptide (LAP)(248 aa), which remains non-covalently linked to mature TGFβ1 rendering it inactive. TGFβ1 is synthesized by many cells, and regulates many other growth factors both in positive and negative manner. It has been shown that TGFβ1 plays an important role in controlling the immune system and shows different activities on different types of cell, or cells at different developmental stages. It is highly expressed in bone and as a potent stimulator of osteoblastic bone formation. TGFβ1 is able to cause chemotaxis, proliferation and differentiation in committed osteoblasts. TGFβ1 is also identified as a disease marker and a therapeutical target for cardiovascular disease.
 
 
参考文献
 
 
 
Assoian R, et al., 1983, J Biol Chem. 258 (11): 7155-60. 
 
Letterio J, et al., 1998, Annu Rev Immunol. 16: 137-61. 
 
Lebman D, et al., 1999, Microbes Infect. 1 (15): 1297-304.
 
Ghadami M, et al., 2000, Am. J. Hum. Genet. 66 (1): 143-7. 
 
Vaughn SP, et al., 2000, Genomics. 66 (1): 119-21.
 
Sánchez-Capelo, A.,2005, Cytokine Growth Factor Rev.16 (1):15-34.
 
Redondo,S.et al., 2007, Cytokine Growth Factor Rev.18 (3-4): 279-86.
 
 
 
 
 
 
 
 
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