北京Brand,null 产品货号： 11058-V07BItem#, H1N1 ( A/California/04/2009 ) NA / Neuraminidase Protein (Active)<br>英文名称： H1N1 ( A/California/04/2009 ) NA / Neuraminidase Protein (Active)

官方网址：http://www.sinobiological.cn/H1N1-Neuraminidase-Protein-g-6425.html
H1N1 ( A/California/04 /2009 ) NA / Neuraminidase Protein
    
 
  H1N1 NA / Neuraminidase Protein Price Inquiry ( Available Sizes )
   200μg:  询价;
 ≥1mg 大包装:  询价
 
 
 H1N1 NA / Neuraminidase蛋白产品信息
    别名:   NA
  
  表达方式:   A DNA sequence encoding the mature form of influenza A virus ( A/California/04/2009 ( H1N1 ) ) neuraminidase ( ACP41107.1 ) ( His 36 -Lys 469 ) was fused with a polyhistidine tag at the N-terminus
  
  种属:   Influenza A Virus H1N1
  
  表达宿主:   Baculovirus
  
 
 
 H1N1 NA / Neuraminidase蛋白质控指标
    纯度:   > 88 % as determined by SDS-PAGE
  SDS-PAGE:
 
 H1N1 NA protein
  
  生物活性:   Measured by its ability to cleave a fluorogenic substrate, 2’-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid
 The specific activity is 800-1200 pmoles/min/µg
  
  内毒素:  Please contact us for more information.  
  稳定性:  Samples are stable for up to twelve months from date of receipt at -70℃  
  预测N端:   His
  
  分子量:  The recombinant influenza H1N1 virus neuraminidase ( A/California/04/2009 ( H1N1 ) ) comprises 450 amino acids with the predicted molecular mass of 50 kDa. The apparent molecular mass of the recombinant protein is approximately 55 kDa in SDS-PAGE under reducing conditions  
  缓冲液:  Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4 , 10% gly  Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
 Please contact us for any concerns or special requirements.
 
  
 
 
 H1N1 NA / Neuraminidase蛋白使用指南
    储存方法:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.  
 
   Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.  
 
 
 H1N1 NA / Neuraminidase蛋白相关产品和研究主题
  Related Areas:
 Enzyme>>Carbohydrate Metabolism Enzymes>>H1N1 neuraminidase/H1N1 NA
 Immunology>>Innate Immunity>>Lysosomal Enzyme>>H1N1 neuraminidase/H1N1 NA
 Virus>>Influenza Virus>>H1N1 neuraminidase/H1N1 NA
 Proteins:
    Products  Source (CLICK for detailed Info. and Price)  Molecule  Description  Cat No  
  Protein  Influenza Neuraminidase (NA)
 H1N1, A/California/04/2009  NA  Fc Tag  11058-V01H  
  Protein  Influenza Neuraminidase (NA)
 H1N1, A/California/04/2009  NA  His Tag  11058-V07H  
  Protein  Influenza Neuraminidase (NA)
 H1N1, A/California/04/2009  NA  His Tag  11058-V07B  
  Protein  Influenza Neuraminidase (NA)
 H1N1, A/California/04/2009  NA  His Tag  11058-V07HC  
  Protein  Influenza Neuraminidase (NA)
 H1N1, A/California/04/2009  NA   -  11058-VNAHC  
  Protein  Influenza Neuraminidase (NA)
 H1N1, A/California/04/2009  NA   -  11058-VNAHC1  
 
 
 Antibodies:
    Products  Antigen Source 
 (CLICK for detailed Info. and Price)  Antigen
 Molecule  Application  Cat No  
  MAb  Influenza Antibody to H1N1, 
 Mouse Anti H1N1 MAb  NA  WB, ELISA  11058-MM04  
 
 
 
 Related Influenza Virus Research Tools
   Influenza Virus Research Tools
 Influenza Neuraminidase & Antibody
 Influenza Neuraminidase (NA) Protein
 H1N1 Neuraminidase
 A/California/04/2009
 
 
 H1N1 NA / Neuraminidase蛋白背景综述
 Neuraminidase ( NA ) and hemagglutinin ( HA ) are major membrane glycoproteins found on the surface of influenza virus. NA, also called sialidases, specifically catalyze the hydrolysis removal of terminal sialic acid residues from viral and cellular glycoconjugates. It is known that HA binds to the sialic acid-containing receptors on the surface of host cells during initial infection, and at the end of an infectious cycle, NA cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. NA thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell. NA is a single-pass type II membrane protein which exists as a homotetramer, and the transmembrane domain is involved in lipid raft association during intracellular transport. NA is suggested to play a role in the determination of host range restriction on replication and virulence. Nine subtypes of NA have been identified, and subtypes N1 and N2 have been positively linked to epidemics in man.
 参考文献
   Barman, S. and Nayak, D.P. 2000, J. Virol. 74: 6538-6545
 Colman, P.M. et al., 1983, Nature. 303: 41-44
 Suzuki, T. et al., 2005, J. Virol. 79: 11705-11715
 von, Itzstein, M. 2007, Nat. Rev. Drug. Discov. 6: 967-974