293细胞转染套装
型号:null    产品货号： SF293T1
价格:请致电：010-57128832,18610462672
品牌: 北京

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7A819); background: -webkit-gradient(linear,left top,left bottom,from(#D1EA74),to(#77A819));" align="center" border=0 cellPadding=0 cellSpacing=0>href="http://www.sinobiological.cn/H1N1-Neuraminidase-Protein-g-5456.html">Influenza Neuraminidase (NA)
H1N1, A/California/04/2009 NA  - 11058-VNAHC1

Antibodies:

Products Antigen Source
(CLICK for detailed Info. and Price)		 Antigen
Molecule		 Application Cat No
MAb Influenza Antibody to H1N1,
Mouse Anti H1N1 MAb		 NA WB, ELISA 11058-MM04

Related Influenza Virus Research Tools

H1N1 NA蛋白背景综述

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. NA, also called sialidases, specifically catalyze the hydrolysis removal of terminal sialic acid residues from viral and cellular glycoconjugates. It is known that HA binds to the sialic acid-containing receptors on the surface of host cells during initial infection, and at the end of an infectious cycle, NA cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. NA is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell. NA is a single-pass type I I membrane protein which exists as a homotetramer, and the transmembrane domain is involved in lipid raft association during intracellular transport. NA is suggested to play a role in the determination of host range restriction on replication and virulence. Nine subtypes of NA have been identified, and subtypes N1 and N2 have been positively linked to epidemics in man.

参考文献

  1. Barman, S. et al., 2000, J. Virol. 74: 6538-6545.
  2. Colman, PM. et al., 1983, Nature. 303: 41-44.
  3. Suzuki, T. et al., 2005, J. Virol. 79: 11705-11715.
  4. von, Itzstein, M. 2007, Nat. Rev. Drug. Discov. 6: 967-974.