重组人白介素6(IL-6)细胞培养用 英文名称: Recombinant Human IL-6 |
型号:null 产品货号: HZ-1058 |
价格:请致电:010-57128832,18610462672 |
品牌: 美国 试剂级别: 细胞培养级 |
IL6/GCSF/MGF 家族的细胞因子是含有约170-180个氨基酸残基的糖蛋白,它们含有四个保守的cys残基形成两对二硫键并由此构成致密的球状构象(和其它白介素类似)。这些结构中有一半是由4条α 螺旋组成的左手束型结构构成的,这些螺旋都是反向平行,含有由2个两股反向β折叠结构组成的接头。第4个α 螺旋结构对该蛋白的生物学活性很重要。 IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues
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