Nebramycin II; APRAMYCIN SULFATE;硫酸安普霉素;称阿泊拉霉素;Apramycin sulfate salt
英文名称: Apramycin sulfate salt 硫酸安普霉素
型号:null    产品货号: Sigma A2024
价格:请致电:010-57128832,18610462672
品牌: sigma

APRAMYCIN SULFATE 硫酸安普霉素

Synonym:

Nebramycin II; APRAMYCIN SULFATE;硫酸安普霉素;阿泊拉霉素;Apramycin sulfate salt

 

Product Description

Sigma Prod. No. A-2024

CAS NUMBER: 65710-07-8

PHYSICAL PROPERTIES:

Appearance: Faint yellow powder

Molecular formula: C21H41N5O11 · x H2SO4

Molecular weight: 539.58 (free base)

storage temp. : 2-8°C

assay: ~95.5% (TLC)

Apramycin is an aminoglycoside antibiotic produced by a strain of Streptomyces tenebrarius. Thecompound is used as the sulfate in veterinary practice(通过干扰原核生物核蛋白质的合成而抑制细菌的繁殖)

 

STABILITY / STORAGE AS SUPPLIED:

Store desiccated at 2-8EC.

 

SOLUBILITY / SOLUTION STABILITY:

Aqueous solutions at 25 mg/mL are faint yellow. No solution stability data are currently available.

 

APPLICATIONS:

1. An oral composition of 20 g apramycin sulfate, 1 g pyridoxal HCl, 10 g sodium alginate,

10 g glycine and about 30 powdered apples were fed to calves and swine in order to treat diarrhea. Pyridoxal HCl was added to enhance the bactericidal activity of apramycin sulfate.3

2. Under the Federal Food, Drug and Cosmetics Act, feed containing 150 g apramycin per ton may be used to control colibacillosis.4

3. Apramycin is a potent inhibitor of protein synthesis in bacteria in vivo and in vitro. To a limited extent, it induces translation errors in cell-free systems from Escherichia coli supplemented with poly(U). Apramycin also inhibits the translocation step of protein synthesis in vivo (e.g., in protoplasts of Bacillus megaterium), and in vitro (e.g., in cell-free systems from E. coli). This may be the drug’s primary inhibitory effect. 5

4. Apramycin sulfate is an aminocyclitol antibiotic whose antibacterial activity has been tested in comparison with neomycin and streptomycin. Of the strains tested, 99% were sensitive to apramycin sulfate, compared to 93% for neomycin and 48% for streptomycin. In vitro resistance development to apramycin sulfate was gradual

 

Ordering Information

Description

Quantity

Price(RMB)

促销价(RMB

Cat. no.

产地

APRAMYCIN SULFATE

1g

694

612

A2024

Sigma

5g

2368

2280

A2024

Sigma