Size  100ug
Cat code  200675
Species Cross-reactivity  H,M
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG1
Molecular Weight  55kDa
Sensitivity  This antibody detects endogenous levels of BECN1 and does not cross-react with related proteins.
Immunogen  Purified recombinant human BECN1 protein fragments expressed in E.coli.
UniProt Number  Q14457
GeneBank ID  NM_003766.3
Subcellular location  Golgi apparatus ? trans-Golgi network membrane; Peripheral membrane protein.
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername  Coiled-coil myosin-like BCL2-interacting proteinProtein GT197
Gene_symbol  ATG6; VPS30; beclin1 
Summary  Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).
UniPort summary  Function  Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
Application Images :  
Western blot detection of BECN1 in Mouse brain,A431&Hela cell lysates using BECN1 antibody (1:1000 diluted).Predicted band size:52KDa.Observed band size:55KDa