Size 100ug
Cat code 200319
Species Cross-reactivity H,M
Key Application WB,IHC,ICC
Host Mouse
Antibody type Monoclonal antibody
Purified method Affinity purified
Isotype IgG1
Molecular Weight 60kDa
Sensitivity This antibody detects endogenous levels TBLR1 and does not cross-react with related proteins.
Immunogen Purified recombinant human TBLR1 protein fragments expressed in E.coli.
UniProt Number Q9BZK7
GeneBank ID AF314544
Subcellular location Nucleus
Formulation Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername C21; DC42; IRA1; FLJ12894
Gene_symbol C21; DC42; IRA1; TBLR1
Summary TBLR1 is an F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. It plays an essential role in transcription activation mediated by nuclear receptors and probably acts as an integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of the N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
UniPort summary Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, th ereby allowing cofactor exchange, and transcription activation.
Application Images :
Western blot detection of TBLR1 antibody in Mouse brain,Mouse heart&K562 cell lysates using TBLR1 antibody (1:1000 diluted).Predicted band size: 60KDaObserved band size: 60Kda.
Immunocytochemistry of HeLa cells using anti- TBLR1 antibody diluted 1:150.
IHC of paraffin-embedded huma breast cancer using anti- TBLR1 diluted 1/500-1/1000
