Size  100ug
Cat code  200452
Species Cross-reactivity  H
Key Application  WB
Host  Mouse
Antibody type  Monoclonal antibody
Purified method  Affinity purified
Isotype  IgG2b
Molecular Weight  38kDa
Sensitivity  This antibody detects endogenous levels of PPP1CC and does not cross-react with related proteins.
Immunogen  Purified recombinant human PPP1CC protein fragments expressed in E.coli.
UniProt Number  P36873
GeneBank ID  NM_002710
Subcellular location  Cytoplasm.Nucleus.Nucleus ? nucleolus.Nucleus ? nucleoplasm.Nucleus speckle.Chromosome ? centromere ? kinetochore.Cleavage furrow.Midbody.Mitochondrion.
Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.
Altername  EC 3.1.3.16;PP 1G;PP-1G;PP1G;PP1G_HUMAN;PP1gamma;PPP 1G;PPP1CC;PPP1CC protein;PPP1G;Protein phosphatase 1 catalytic subunit gamma isoform;Protein phosphatase 1C catalytic subunit;Protein phosphatase 1C subunit;Protein phosphatase 2C gamma isoform;Serine/threonine phosphatase 1 gamma;Serine/threonine protein phosphatase PP1 gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.
Gene_symbol  PP1C;PP-1G;PPP1G.
Summary  The protein encoded by this gene belongs to the protein phosphatase family,PP1 subfamily.PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes,including cell division.It is expressed in mammalian cells as three closely related isoforms,alpha,beta/delta and gamma,which have distinct localization patterns.This gene encodes the gamma isozyme.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq,Oct 2011]
UniPort summary  Function  Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets.Protein phosphatase 1(PP1)is essential for cell division,and participates in the regulation of glycogen metabolism,muscle contractility and protein synthesis.Dephosphorylates RPS6KB1.Involved in regulation of ionic conductances and long-term synaptic plasticity.May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.Component of the PTW/PP1 phosphatase complex,which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Application Images :  
Western blot detection of PPP1CC antibody in Hela,293T and Jurkat cell lysates using PPP1CC antibody (1:500 diluted).Predicted band size:38KDa.Observed band size:38KDa.