人参皂苷Ra3
英文名称: Ginsenoside Ra3
型号:null    产品货号: 90985-77-6
价格:请致电:010-57128832,18610462672
品牌: 吉林长春

Ginsenoside Ra3 Biological Activity

IC50 Value & Target:

In Vitro: Plasma 20(S)-protopanaxadiol and 20(S)-protopanaxatriol could be used as pharmacokinetic markers to reflect the subjects microbial activities, as well as the timely-changes and interindividual differences in plasma levels of their respective oxidized metabolites. [2].

In Vivo: After ingestion of Sanchi extract, ginsenosides Ra3, Rb1, Rd, Rg1, F1, Rh1, and notoginsenoside R1 were measured in plasma samples. Deglycosylated metabolites Compound-K, protopanaxadiol, and protopanaxatriol were also detected in plasma. Notably, several metabolites of protopanaxadiol and protopanaxatriol were found in human plasma and characterized, the plasma concentrations of which were significantly higher than those of the circulating ginsenosides. Conclusion: Although the ginsenoside aglycones protopanaxadiol and protopanaxatriol were not contained in the test Sanqi extract, their oxidized metabolites represented a class of major circulating compounds after ingestion of the herbal extract to humans. [1]. The PK profiles of the Sanqi ginsenosides in humans were comparable to those found in rats. Slight interspecies differences could have been due to humans being relatively poor biliary excretors compared with rats.[3].

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