Human Growth Factors & Cytokines
Recombinant Human IGF-BP3


 
		Synonyms :
***-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein
		Description :
IGF-BP3 is a 30 kDa cysteine-rich secreted protein.  It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets.  In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity.  Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly.  The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF.  Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
		Catalog #:
100-08
		Source :
E.coli
		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
		Biological Activity :
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7.  The expected ED50 for this effect is ≤ 0.2 μg/ml in presence of 15 ng/ml of human IGF-II.
Selected References :
Selected List of References Citing This PeproTech Product
                AA Sequence :
GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK 
		PubMed Link :
IGF+AND+Binding+AND+Protein-3
Country of Origin :
USA
        Size A
5μg
$80 
 
 
        Size B
25μg
$195 
 
 
        Size C
1mg
$3000 
 
 
Special                     Sizes: 
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Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.