Human Growth Factors & Cytokines
Recombinant Human IGF-BP5


 
		Synonyms :
***-like Growth Factor-Binding Protein5
		Description :
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids.  Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II.  IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by vascular smooth muscle cells.  It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts.  Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells.  IGFBP-5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.  Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.
		Catalog #:
100-05
		Source :
E.coli
		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses
		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
		Biological Activity :
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is ≤ 0.3 μg/ml in the presence of 15 ng/ml of human IGF-II.
Selected References :
Selected List of References Citing This PeproTech Product
                AA Sequence :
MLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQSCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ VKIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDRRKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKYGM KLPGMEYVDG DFQCHTFDSS NVS 
		PubMed Link :
IGF Binding Protein 5
Country of Origin :
USA
        Size A
5μg
$80 
 
 
        Size B
25μg
$195 
 
 
        Size C
1mg
$3000 
 
 
Special                     Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.