英文名称： Recombinant Human FGFR2a (IIIc) Fc
Recombinant Human FGFR2a (IIIc) Fc
Catalog Number:
160-03
Synonyms:
Fibroblast Growth Factor Receptor 2 alpha, BEK, KGFR
Description:
FGF家族通过促进细胞的增殖和分化，在胎儿发育和产后生长以及各种组织的再生过程中发挥着核心作用。 FGF配体结合到I型跨膜酪氨酸激酶受体家族，进而通过一系列特定的酪氨酸残基自***酸化使受体二聚化并激活受体。现已知有四个基因编码结构上相关的FGF受体（FGFR-1-4）。FGFR mRNA选择性剪接产生了多种形式的FGF受体（FGFR-1 -3）。FGF受体的不同形式表现出与配体结合的特异性。例如，FGFR1a（IIc）主要与FGF-酸性（FGF1）和FGF-碱性（FGF2）相互作用。包括FGFR-1和FGFR-2在内的不同剪接体中有所有的三个免疫球蛋白结构域的被称为α-异构体，或仅含IgII和 IgIII的被称为β异构体。只有α-异构体已被确定为FGFR-3和FGFR-4。FGF受体1-3形式的剪接包含由两个相互排斥的替代外显子编码的IgIII域的C-末端半部，形成FGF受体与可替代的IgIII域（IIIb和IIIc）。重组人FGFR2a（IIIc）是一个分子量为 65.6 kDa，含有589个氨基酸的蛋白质。在还原条件下，FGFR2a在SDS-PAGE上迁移至100-110 kDa的位置。
AA Sequence:
(Monomer)R PSFSLVEDTT LEPEEPPTKY QISQPEVYVA APGESLEVRC LLKDAAVISW TKDGVHLGPN NRTVLIGEYL QIKGATPRDS GLYACTASRT VDSETWYFMV NVTDAISSGD DEDDTDGAED FVSENSNNKR APYWTNTEKM EKRLHAVPAA NTVKFRCPAG GNPMPTMRWL KNGKEFKQEH RIGGYKVRNQ HWSLIMESVV PSDKGNYTCV VENEYGSINH TYHLDVVERS PHRPILQAGL PANASTVVGG DVEFVCKVYS DAQPHIQWIK HVEKNGSKYG PDGLPYLKVL KAAGVNTTDK EIEVLYIRNV TFEDAGEYTC LAGNSIGISF HSAWLTVLPA PGREKEITAS PDYLEGGPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Assay#1: Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED50 is ≤ 0.5 ng/ml corresponding to a specific activity of ≥ 2 x 106 units/mg.
Assay #2: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Assay #2: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Cross Reactivity:
Human, Mouse
Research Interests:
 | Angiogenesis/ Cardiovascular |  | Cancer |
 | Cell Culture |  | FGF Superfamily |
 | Inflammation |  | Neurobiology |
 | Proliferation |  | Stem Cells & Differentiation |
 | Wound Healing | ||
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.