Synonyms : | Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) |
Description : | IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues. |
Catalog #: | 200-01A |
Source : | E.coli |
Purity : | Greater than 98% by SDS-PAGE gel and HPLC analyses. |
Endotoxin Level : | Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
Biological Activity : | The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg. |
Selected References : | Selected List of References Citing This PeproTech Product |
AA Sequence : | SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA |
PubMed Link : | IL-1+AND+alpha |
Country of Origin : | USA |
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| | Size A | 2μg | $80 |  | | | | Size B | 10μg | $195 | | | | | Size C | 1mg | $5200 | | | |
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| Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request. |
| Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures. |
