人肝细胞生长因子

Recombinant Human HGF

Catalog Number:

100-39

Synonyms:

Scatter Factor （SF）, Hepatopoietin （HPTA）

Description:

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains （α-chain and β-chain） held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.*Manufactured using （BTI-Tn-5B1-4） cells under license from Boyce Thompson Institute for Plant Research, Inc.

Cross Reactivity:

Human, Monkey, Pig, Rat, Mouse + Chicken, Mouse, N/A, Mouse + Bacteria

Research Interests:

	Angiogenesis/ Cardiovascular		Cancer
	Diabetes / Weight Regulation		Immune System
	Inflammation		Neurobiology
	Proliferation		Stem Cells & Differentiation
	Wound Healing		Allergy
	Transplantation

Country of Origin:

USA