英文名称： NXF1 (D5X4G) Rabbit mAb
NXF1 (D5X4G) Rabbit mAb
| 品牌 | 货号 | 规格 | 促销价（元） | 储存 |
| CST | 12735s | 100ul | 2200 | -20℃（不可冷冻） |
抗体信息
| 中文名称 | 核RNA输出因子 |
| 英文全称 | Nuclear RNA export factor 1 |
| Host宿主 | Rabbit |
| Isotype | IgG |
| Reactivity反应性 | Human, Mouse, Rat, Monkey |
| 应用 | western blot （1:1000） |
| 目的蛋白分子量 | 70kDa |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln211 of human NXF1 protein. |
背景介绍
mRNA export is a process that is tightly coupled to mRNA splicing (1-4). Splicing and packaging of mRNAs in the form of an mRNA-protein complex (mRNP) leads to the recruitment of the mRNA export adaptor THOC4/ALY, via its interaction with the splicing factor UAP56, forming a large complex termed the transcription-export complex (TREX) (1,2,5). THOC4/ALY then directly interacts with NXF1/TAP, a part of the heterodimer that targets the mRNP to the nuclear pore complex, resulting in the shuttling of mRNP out of the nucleus and into the cytoplasm (1-3,6).
Western blot analysis of extracts from various cell lines using NXF1 (D5X4G) Rabbit mAb.
参考文献
1. Katahira, J. (2012) Biochim Biophys Acta 1819, 507-13.
2. Siddiqui, N. and Borden, K.L. (2012) Wiley Interdiscip Rev RNA 3, 13-25.
3. Reed, R. and Magni, K. (2001) Nat Cell Biol 3, E201-4.
4. Masuda, S. et al. (2005) Genes Dev 19, 1512-7.
5. Luo, M.L. et al. (2001) Nature 413, 644-7.
6. Kang, Y. and Cullen, B.R. (1999) Genes Dev 13, 1126-39.