A highly selective, potent and cell-permeable inhibitor of p38 MAP
kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM,
as measured in recombinant human p38), and selectively inhibits the
p38a and ß isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and
SAPK2b/p38ß2 respectively).
Jiang et al (1996)J.Biol.Chem. 271 17920. Frantz et al (1998) Biochemistry37
13846. Nemoto et al (1998)J.Biol.Chem. 273 16415.