SU11274 is a highly specific inhibitor of c-Met , with in vitro IC50
for the Met enzyme at 0.012 umol/L. The inhibitor did not affect
other tyrosine kinase oncoproteins,including BCR-ABL,TEL-JAK2,
TEL-PDGF_R, or TEL-ABL. Inhibition of the Met kinase activity
by SU11274 led to time-and dose-dependent reduced cell growth.
Koon EC, Ma PC, Salgia R, Welch WR, et al. Int J Gynecol Cancer.2008
Sep-Oct;18(5):976-84. Epub 2007 Nov 16.Ma PC, Jagadeeswaran R,
Jagadeesh S,et al.Cancer Res. 2005 Feb 15;65(4):1479-88.