KCNAB1/Kv beta 1,电压门控钾通道蛋白1抗体

产品编号HZ-8691R
英文名称KCNAB1/Kv beta 1
中文名称电压门控钾通道蛋白1抗体
别 名hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCAB1_HUMAN; KCNA1B; KCNAB1; KV-BETA-1; Kvb1.3; Voltage-gated potassium channel beta-1 subunit; Voltage-gated potassium channel subunit beta-1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
KCNAB1/Kv beta 1,电压门控钾通道蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human KCNAB1/Kv beta 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
KCNAB1/Kv beta 1,电压门控钾通道蛋白1抗体PubMedPubMed
产品介绍background:
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming å subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV∫, also known as KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1), is a 419 amino acid accessory K+ channel protein that exists as three alternatively spliced isoforms and regulates the activity of the pore-forming å subunit. It is expressed in brain, with highest levels detected in caudate nucleus, hippocampus and thalamus.

Function:
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.

Subunit:
Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1 (By similarity).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.

Similarity:
Belongs to the shaker potassium channel beta subunit family.

Database links:
Entrez Gene: 395730 Chicken
Entrez Gene: 526133 Cow
Entrez Gene: 7881 Human
Entrez Gene: 16497 Mouse
Entrez Gene: 100125830 Pig
Entrez Gene: 29737 Rat
GenBank: NP_751891 Human
Omim: 601141 Human
SwissProt: Q9PWR1 Chicken
SwissProt: Q4PJK1 Cow
SwissProt: Q14722 Human
SwissProt: P63143 Mouse
SwissProt: P63144 Rat
Unigene: 654519 Human
Unigene: 703187 Human
Unigene: 316402 Mouse
Unigene: 32090 Rat

KCNAB1/Kv beta 1,电压门控钾通道蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.