Pacific Blue anti-mouse CD3e
英文名称： Pacific Blue anti-mouse CD3e
型号:null    抗体货号： 102410
价格:请致电：010-57128832,18610462672
品牌: 美国/中国    产品商标: biolegend

上海信裕生物科技有限公司是一家集研发、生产、销售、服务于一体的国际领先生物高新技术企业，专营基因、蛋白、抗体、Elisa试剂盒、细胞生物学，分子生物学等高质量生物产品。抗体纯化/标记/免疫检测：免疫分析检测是一项应用广泛的技术，利用抗原和抗体的特异性反应进行检测的一种手段，广泛用于医学病理学、免疫组织化学、分子生物学、生物制药等领域的分析研究与技术测定。制备高特异性、高效价的抗体是实验免疫学技术的基础，抗体质量的高低将直接影响试验的成败。抗体纯化能降低非特异性本底，抗体标记能通过标记物的增强放大效应提高检测灵敏度，采用ELISA、WB、IP、IHC等不同免疫分析技术检测各种样品中特定的目的蛋白。

d freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Plakophilin 2,桥粒斑菲素蛋白2抗体PubMedPubMed
产品介绍background:
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains, and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin-1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration. Plakophilin-2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin-3 plays a role in both desmosome-dependent adhesion and signaling pathways. Plakophilin-4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.

Function:
May play a role in junctional plaques.

Subunit:
Interacts with DSC2.

Subcellular Location:
Nucleus. Cell junction, desmosome.Note=Nuclear and associated with desmosomes.

Tissue Specificity:
Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.

Plakophilin 2,桥粒斑菲素蛋白2抗体Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9) [MIM:609040]; also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.

Similarity:
Belongs to the beta-catenin family.
Contains 8 ARM repeats.

Database links:
Entrez Gene: 537784 Cow
Entrez Gene: 486613 Dog
Entrez Gene: 101150898 Gorilla
Entrez Gene: 101830795 Hamster
Entrez Gene: 100070065 Horse
Entrez Gene: 5318 Human
Entrez Gene: 67451 Mouse
Entrez Gene: 100347738 Rabbit
Entrez Gene: 287925 Rat
Omim: 602861 Human
SwissProt: Q99959 Human
Unigene: 164384 Human
Unigene: 2252 Mouse
Unigene: 27944 Rat

Plakophilin 2,桥粒斑菲素蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片
Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-Plakophilin 2 Polyclonal Antibody, Unconjugated(HZ-11063R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-Plakophilin 2 Polyclonal Antibody, Unconjugated(HZ-11063R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining