COMMD7,铜代谢结构域蛋白7抗体

产品编号HZ-8036R
英文名称COMMD7
中文名称铜代谢结构域蛋白7抗体
别 名C20orf92; Chromosome 20 open reading frame 92; COMM domain containing 7; COMM domain containing protein 7; COMMD 7; dJ1085F17.3; FLJ14987; MGC33315; OTTHUMP00000030609; COMD7_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig,
COMMD7,铜代谢结构域蛋白7抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from Human COMMD7
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
COMMD7,铜代谢结构域蛋白7抗体PubMedPubMed
产品介绍background:
COMMD is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. The prototype of this family, MURR1/COMMD1, suppresses NFkB by affecting the association of NF-kappaB with chromatin. COMMD7 (COMM domain-containing protein 7) interacts with COMMD1 via its COMM domain. It also associates with the NF-kappa-B complex and suppresses its transcriptional activity.

Function:
Associates with the NF-kappa-B complex and suppresses its transcriptional activity.

Subunit:
Interacts (via COMM domain) with COMMD1 (via COMM domain).

Tissue Specificity:
Widely expressed with highest expression in lung.

Similarity:
Contains 1 COMM domain.

COMMD7,铜代谢结构域蛋白7抗体Database links:
UniProtKB/Swiss-Prot: Q86VX2.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.