BS69,腺病毒5结合蛋白BS69/骨形态发生蛋白受体相关分子1抗体

产品编号HZ-7697R
英文名称BS69
中文名称腺病毒5结合蛋白BS69/骨形态发生蛋白受体相关分子1抗体
别 名Adenovirus 5 E1A binding protein; Bone morphogenetic protein receptor associated molecule 1; BRAM1; BS69 variant 1; BS69 variant 2; BS69 variant 3; BS69 variant 4; Zinc finger MYND domain containing 11; ZMYND11.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Horse, Sheep,
BS69,腺病毒5结合蛋白BS69/骨形态发生蛋白受体相关分子1抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量71kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A binding protein (535-584aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BS69,腺病毒5结合蛋白BS69/骨形态发生蛋白受体相关分子1抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:
Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.

Subunit:
Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with E2F6.

Subcellular Location:
Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated, leading to proteasomal degradation.

DISEASE:

Similarity:
Contains 1 bromo domain.
Contains 1 MYND-type zinc finger.
Contains 1 PHD-type zinc finger.
Contains 1 PWWP domain.

Gene ID:
10771

BS69,腺病毒5结合蛋白BS69/骨形态发生蛋白受体相关分子1抗体Database links:
Entrez Gene: 10771 Human
Entrez Gene: 66505 Mouse
Entrez Gene: 291259 Rat
GenBank: NP_006615 Human
GenBank: NP_997644 Human
Omim: 608668 Human
SwissProt: Q15326 Human
SwissProt: Q8R5C8 Mouse
Unigene: 292265 Human
Unigene: 397307 Mouse
Unigene: 38301 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.