CBX7,CBX7蛋白抗体

产品编号HZ-7373R
英文名称CBX7
中文名称CBX7蛋白抗体
别 名CBX-7; CBX7_HUMAN; Cbx 7; CBX7; Chromobox homolog 7; Chromobox protein homolog 7; OTTHUMP00000028984.
说 明 书0.1ml 0.2ml
研究领域细胞生物 转运蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Chimpanzee,
CBX7,CBX7蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CBX7
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CBX7,CBX7蛋白抗体PubMedPubMed
产品介绍background:
Control of cell proliferation by Polycomb group proteins (PcG) is an important facet of cellular homeostasis and its disruption can promote tumorigenesis. CBX7 is a novel PcG protein which is found to control the growth of normal cells. CBX7 is a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its localization to nuclear Polycomb bodies. CBX7 extends the lifespan of a wide range of normal human cells and immortalizes mouse fibroblasts by downregulating expression of the Ink4a/Arf locus. CBX7 does not inter-function or colocalize with Bmi1, and both can exert their actions independently of each other as shown by reverse genetics. CBX7 was highly expressed in three different prostate cancer cell lines and present at elevated levels in normal prostate. (Gil et al., 2004).

Subcellular Location:
Nuclear

Similarity:
Contains 1 chromo domain.

Gene ID:
23492

Database links:
Entrez Gene: 23492 Human
Entrez Gene: 525770 Cow
Entrez Gene: 52609 Mouse
Entrez Gene: 362962 Rat
Omim: 608457 Human
SwissProt: O95931 Human
SwissProt: Q8VDS3 Mouse
SwissProt: P60889 Rat
Unigene: 356416 Human
Unigene: 12512 Rat

CBX7,CBX7蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.