CRLR,降钙素基因相关肽1型受体抗体
产品编号HZ-1860R
英文名称CRLR
中文名称降钙素基因相关肽1型受体抗体
别 名CGRPR; calcitonin receptor like precursor; Calcitonin gene related peptide type 1 receptor; Calcitonin receptor like; CALCRL; CGRP type 1 receptor; CGRPR; Calcitonin gene related peptide type 1 receptor; Calcitonin receptor like; Calcitonin Receptor Like Receptor; CALCRL; CGRP type 1 receptor; CALRL_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 神经生物学 信号转导 G蛋白偶联受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CRLR,降钙素基因相关肽1型受体抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CGRPR1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CRLR,降钙素基因相关肽1型受体抗体PubMedPubMed
产品介绍background:
CRLR is a receptor for calcitonin gene related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.
Function:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit:
Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Predominantly expressed in the lung and heart.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
Gene ID:
10203
CRLR,降钙素基因相关肽1型受体抗体Database links:
Entrez Gene: 10203 Human
Entrez Gene: 54598 Mouse
Entrez Gene: 397172 Pig
Entrez Gene: 25029 Rat
Entrez Gene: 527140 Cow
Omim: 114190 Human
SwissProt: Q16602 Human
SwissProt: Q9R1W5 Mouse
SwissProt: Q8WN93 Pig
SwissProt: Q63118 Rat
Unigene: 470882 Human
Unigene: 11202 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片 | Western blot analysis of extracts from Lung lumph using CRLR antibody. (Primary dilution:1:300) Tissue/cell: Rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CRLR Polyclonal Antibody, Unconjugated(HZ-1860R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |