CUEDC2,CUE结构域蛋白2抗体

产品编号HZ-4608R
英文名称CUEDC2
中文名称CUE结构域蛋白2抗体
别 名bA18I14.5; C10orf66; Chromosome 10 open reading frame 66; CUE domain containing 2; CUE domain-containing protein 2; CUED2; CUED2_HUMAN; Cuedc2; MGC2491; OTTHUMP00000020368.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 染色质和核信号 信号转导 激酶和***酸酶 表观遗传学 泛素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
CUEDC2,CUE结构域蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CUE domain containing 2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CUEDC2,CUE结构域蛋白2抗体PubMedPubMed
产品介绍background:
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Function:
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Subunit:
Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

DISEASE:
Note=May predict the clinical outcome of *** therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to *** treatment as effectively as those with tumors with low expression.

CUEDC2,CUE结构域蛋白2抗体Similarity:
Belongs to the CUEDC2 family.
Contains 1 CUE domain.

Database links:
Entrez Gene: 79004 Human
Entrez Gene: 67116 Mouse
Entrez Gene: 294009 Rat
Omim: 614142 Human
SwissProt: Q9H467 Human
SwissProt: Q9CXX9 Mouse
SwissProt: A1L131 Rat
Unigene: 500874 Human
Unigene: 218848 Mouse
Unigene: 19673 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CUEDC2(CUE Domain Containing 2)能够结合IKKα和IKKβ,并通过使IKKα和IKKβ去***酸化而抑制NF-κ信号通路。CUEDC2能特异性结合雌***受体（ER），并导致ER的泛素化降解.抑制乳腺癌细胞的生长。