Calponin 1 + 2 + 3,钙结合蛋白Calponin抗体

产品编号HZ-4902R
英文名称Calponin 1 + 2 + 3
中文名称钙结合蛋白Calponin抗体
别 名smooth muscle; Basic calponin; Calponin 1; Calponin 2; Calponin 3; Calponin1; Calponin2; Calponin3; Calponin-1; Calponin-2; Calponin-3; Calponin 1 basic smooth muscle; Calponin H1; Calponin H1 smooth muscle; Calponins basic; CNN 1; Cnn1; CNN2_HUMAN; Sm Calp; SMCC.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 信号转导 干细胞 结合蛋白 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
Calponin 1 + 2 + 3,钙结合蛋白Calponin抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Calponin 1/2/3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Calponin 1 + 2 + 3,钙结合蛋白Calponin抗体PubMedPubMed
产品介绍background:
Calponin regulates smooth muscle cell contraction and is a marker of smooth muscle cell differentiation. Calponin, an Actin- and Tropomyosin-binding protein, is characterized as an inhibitory factor of smooth-muscle actomyosin activity. Calponin is implicated in the regulation of smooth muscle contraction through its interaction with F-Actin and inhibition of the Actin-activated MgATPase activity of phosphorylated myosin. Both properties are lost following phosphorylation (primarily at Serine 175) by protein kinase C or calmodulin-dependent protein kinase II. The three forms of Calponin, Calponin 1 (basic Calponin), Calponin 2 (neutral Calponin) and Calponin 3 (acidic Calponin) are found in smooth muscle tissue. Additionally, Calponin 2 is found in heart muscle tissue and Calponin 3 is found in the brain.

Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Subcellular Location:

Tissue Specificity:
Heart and smooth muscle.

Post-translational modifications:

Similarity:
Belongs to the calponin family.
Contains 3 calponin-like repeats.
Contains 1 CH (calponin-homology) domain.

Gene ID:
1265

Calponin 1 + 2 + 3,钙结合蛋白Calponin抗体Database links:
Entrez Gene: 1265 Human
Omim: 602373 Human
SwissProt: Q99439 Human
Unigene: 651512 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.