DYNLRB1,胞质动力蛋白轻链抗体2A抗体

产品编号HZ-14470R
英文名称DYNLRB1
中文名称胞质动力蛋白轻链抗体2A抗体
别 名BITH; bithoraxoid like protein; BLP; cytoplasmic dynein light chain 2A; DNCL2A; DNLC2A; dynein associated protein HKM23; dynein associated protein Km23; Dynein light chain 2A, cytoplasmic; dynein, cytoplasmic, light polypeptide 2A; dynein, light chain, roadblock type 1; HSPC162; Roadblock 1; DLRB1_HUMAN; roadblock domain containing 1; Roadblock domain containing protein 1; ROBL/LC7 like 1; ROBLD1.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Rabbit,
DYNLRB1,胞质动力蛋白轻链抗体2A抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量11kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DYNLRB1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DYNLRB1,胞质动力蛋白轻链抗体2A抗体PubMedPubMed
产品介绍background:
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

Function:
DYNLRB1 is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.

Similarity:
Belongs to the GAMAD family.

Gene ID:
83658

Database links:
Entrez Gene: 83658 Human
Omim: 607167 Human
SwissProt: Q9NP97 Human

DYNLRB1,胞质动力蛋白轻链抗体2A抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.