DPPL1,***脂酸***酸酶HTPAP抗体

产品编号HZ-6250R
英文名称DPPL1
中文名称***脂酸***酸酶HTPAP抗体
别 名diacylglycerol pyrophosphate like 1; DPPL1; EC=3.1.3.4; HTPAP; Phosphatidate phosphatase PPAPDC1B; Phosphatidic acid phosphatase type 2 domain-containing protein 1B; PPAPDC1B; PPC1B_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 信号转导 激酶和***酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
DPPL1,***脂酸***酸酶HTPAP抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DPPL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DPPL1,***脂酸***酸酶HTPAP抗体PubMedPubMed
产品介绍background:
DPPL1 and is a 223 amino acid protein that is localized to the cellular membrane. HTPAP is a multi-pass membrane protein which is thought to possess six transmembrane spanning domains and is expressed as two isoforms. HTPAP is a member of the PAP related phosphoesterase family and the gene encoding HTPAP is highly conserved among many species. HTPAP functions as a PAP for lipid phosphate substrates, including PA (phosphatidate), LPA (lysophatidate) and DGPP (diacylglycerol pyrophosphate), but preferentially targets DGPP. Breast cancer tumors, specifically those in which ER (estrogen receptor) is present in high amounts, exhibit upregulation of the gene which encodes HTPAP and HTPAP is thought to increase ER activity. Due to the overexpression of HTPAP in ductal breast carcinomas and the observation that, in cases of lower HTPAP expression, tumors grew slower, HTPAP is thought to be an oncogene. In contrast, the gene encoding HTPAP is downregulated in HCC (hepatocellular carcinoma) and is thought to inhibit lung metastasis.

Function:
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.

Subcellular Location:
Membrane; Multi-pass membrane protein

DPPL1,***脂酸***酸酶HTPAP抗体Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the PA-phosphatase related phosphoesterase family.

Database links:
Entrez Gene: 84513 Human
Entrez Gene: 71910 Mouse
Entrez Gene: 680466 Rat
Omim: 610626 Human
SwissProt: Q8NEB5 Human
SwissProt: Q3UMZ3 Mouse
Unigene: 567619 Human
Unigene: 385055 Mouse
Unigene: 199008 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.