Contactin-1,接触蛋白抗体

产品编号HZ-2667R
英文名称Contactin-1
中文名称接触蛋白抗体
别 名CNTN 1; CNTN; Cntn1; CNTN1_HUMAN; Contactin-1; Contactin1; F3; F3cam; Glycoprotein gp135; gp 135; GP135; Neural cell surface protein F3.
说 明 书0.1ml 0.2ml
研究领域免疫学 神经生物学 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
Contactin-1,接触蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量111kDa
细胞定位细胞膜 细胞外基质
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Contactin-1,接触蛋白抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Function:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).

Subunit:
Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR (By similarity).

Subcellular Location:
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Tissue Specificity:
Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.

DISEASE:
Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM) [MIM:612540]. CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.

Contactin-1,接触蛋白抗体Similarity:
Belongs to the immunoglobulin superfamily. Contactin family.
Contains 4 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Gene ID:
1272

Database links:
Entrez Gene: 1272 Human
Entrez Gene: 12805 Mouse
Entrez Gene: 117258 Rat
Omim: 600016 Human
SwissProt: Q12860 Human
SwissProt: P12960 Mouse
SwissProt: Q63198 Rat
Unigene: 143434 Human
Unigene: 470343 Mouse
Unigene: 4911 Mouse
Unigene: 21397 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.