半胱胺酸蛋白酶-10抗体
英文名称: 详见说明书
型号:null    抗体货号: YM-H15832-X
价格:请致电:010-57128832,18610462672
品牌: 进口/国产    产品商标: 上海延慕

上海延慕供应:半胱胺酸蛋白酶-10抗体抗体 抗原抗体 蛋白抗体 结构组织蛋白抗体等等。
上海延慕生化试剂供应商!上海抗体供应商!


【半胱胺酸蛋白酶-10抗体】 相关介绍:
产品货号:YM-H15832-X
产品名称:半胱胺酸蛋白酶-10抗体
浓 度: 1mg/1ml
应用范围: WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500
宿 主: rabbit
适应物种: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,
克 隆 性: 否
保存条件: -20度
亚 型: IgG
规 格:0.1ml/100ug,0.2ml/200ug
产品类型:一抗 单抗 多抗
形 态: Lyophilized or Liquid
免 疫 原: KLH conjugated synthetic peptide derived from human ABI3
克隆类型: polyclonal or monoclonal
运输方式:低温保存运输。
抗体的交叉反应:人,小鼠,大鼠,鸡 ,狗,猪,羊,牛,兔等......
半胱胺酸蛋白酶-10抗体相关标记:此产品本公司有标记的一抗出售,如:HRP标记、PE标记、PE-Cy3标记、PE-CY5标记、RBITC标记Alexa Fluor 350 标记、AlexaFluor 488 标记、Alexa Fluor 555 标记、Alexa Fluor 647 标记、AP标记、APC标记、Biotin标记、Cy3标记、Cy5标记、Cy5.5标记、Cy7标记、FITC标记、Gold标记


半胱胺酸蛋白酶-10抗体稀释方法:
方法1. 实验前,将冻干粉抗体用无菌蒸馏水稀释(或PBS稀释),将稀释后的抗体分装5-10支(20ulx5支或10ulx10支),放入-20℃保存,用一支拿一支,避免反复冻溶。
方法2. 实验前,也可将冻干粉抗体用无菌蒸馏水稀释50ul(或PBS稀释50ul)成原液:再加50%甘油, 放入-20℃保存,用多少吸多少。
方法3. 预试验可做几个梯度1:100、200、400背景高还可做上去,选一个最佳的稀释比例,再正式做,效果最好。工作液的稀释-使用抗体稀释液。
抗体,抗体价格,【半胱胺酸蛋白酶-10抗体】相关:
YM-H11671-X 2'-5'-寡腺苷酸合成酶3抗体 延慕 1mg/1ml
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YM-H11673-X NDUFAF4抗体 延慕 1mg/1ml
YM-H11674-X NDUFS2抗体 延慕 1mg/1ml
YM-H11675-X ***酸化Nemo样激酶抗体 延慕 1mg/1ml
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YM-H11677-X ***酸化NIFK抗体 延慕 1mg/1ml
YM-H11678-X ***酸化核因子2相关因子2(Ser40)抗体 延慕 1mg/1ml
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YM-H11680-X 钠钙交换蛋白3抗体 延慕 1mg/1ml
YM-H11681-X 钠钙交换蛋白1抗体 延慕 1mg/1ml
YM-H11682-X ***酸化细胞核因子NF-κB 延慕 1mg/1ml
YM-H11683-X 嗜中性粒细胞胞浆因子4抗体 延慕 1mg/1ml
YM-H11684-X 核仁***酸蛋白抗体 延慕 1mg/1ml
YM-H11685-X 孤儿核受体TAK1抗体 延慕 1mg/1ml
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YM-H11687-X 谷氨酸受体调节蛋白2抗体 延慕 1mg/1ml
YM-H11688-X 神经肿瘤Nova2抗原抗体 延慕 1mg/1ml
YM-H11689-X *水解酶1抗体 延慕 1mg/1ml
YM-H11690-X G21蛋白质抗体 延慕 1mg/1ml
YM-H11691-X 老年性痴呆蛋白APH2抗体 延慕 1mg/1ml
YM-H11692-X 壬基酚抗体 延慕 1mg/1ml
YM-H11693-X 跨膜受体蛋白Notch-1抗体 延慕 1mg/1ml
YM-H11694-X 核受体辅助抑制因子2抗体 延慕 1mg/1ml
YM-H11695-X 神经降压素抗体 延慕 1mg/1ml
YM-H11696-X 分化相关基因NDRG1抗体 延慕 1mg/1ml
YM-H11697-X NCK衔接蛋白1抗体 延慕 1mg/1ml
YM-H11698-X 末端多聚腺苷酸2蛋白抗体 延慕 1mg/1ml
YM-H11699-X 纤维细胞源性蛋白 延慕 1mg/1ml
YM-H11700-X 鸟氨酸氨基甲酰转移酶抗体 延慕 1mg/1ml
YM-H11701-X 固生蛋白M抗体 延慕 1mg/1ml
YM-H11702-X 抗细胞凋亡蛋白OLFM44抗体 延慕 1mg/1ml
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YM-H11704-X 口腔癌高表达的蛋白1抗体 延慕 1mg/1ml
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YM-H11707-X 卵巢癌相关基因1抗体 延慕 1mg/1ml
YM-H11708-X 泛素特异性蛋白酶Otubain2抗体 延慕 1mg/1ml
YM-H11709-X 氧气调节蛋白150抗体 延慕 1mg/1ml
YM-H11710-X 氧化应激反应蛋白1抗体 延慕 1mg/1ml
YM-H11711-X OS-9蛋白抗体 延慕 1mg/1ml
YM-H11712-X 卵巢癌相关基因2蛋白抗体 延慕 1mg/1ml
YM-H11713-X 癌基因蛋白抑瘤素M抗体 延慕 1mg/1ml
YM-H11714-X 有机溶质转运蛋白OSTβ抗体 延慕 1mg/1ml
YM-H11715-X ***酸化精子尾部结构蛋白抗体 延慕 1mg/1ml
YM-H11716-X 精子尾部结构蛋白抗体 延慕 1mg/1ml


相关标签:抗体 蛋白抗体 标记抗体 抗原抗体
以上就是有关【半胱胺酸蛋白酶-10抗体】的相关详解,如有不懂请来电详谈(电话:021-51866084 QQ:2095001174)!延慕期待与您的合作!

diators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

phospho-c-ABL1+2 (Tyr393+439),***酸化非受体酪氨酸激酶c-Abl抗体Subunit:
Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16, ITGB1 and HCK (By similarity). Interacts with INPPL1/SHIP2. Interacts with the 14-3-3 proteins, YWHAB, YWHAE, YWHAG, YWHAH, SFN AND YWHAZ; the interaction with 14-3-3 proteins requires phosphorylation on Thr-735 and, sequesters ABL1 into the cytoplasm. Interacts with ABI1, ABI2, BCR, CRK, FGR, FYN, HCK, LYN, PSMA7 RAD9A, RAD51, RAD52, TP73 and WASF3. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement.

Subcellular Location:
Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress. Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Acetylated at Lys-711 by EP300 which promotes the cytoplasmic translocation.
Phosphorylation at Tyr-70 by members of the SRC family of kinases disrupts SH3 domain-based autoinhibitory interactions and intermolecular associations, such as that with ABI1, and also enhances kinase activity. Phosphorylation at Tyr-226 and Tyr-393 correlate with increased activity. DNA damage-induced activation of ABL1 requires the function of ATM and Ser-446 phosphorylation. Phosphorylation at Ser-569 has been attributed to a CDC2-associated kinase and is coupled to cell division. Phosphorylation at Ser-618 and Ser-619 by PAK2 increases binding to CRK and reduces binding to ABI1. Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic translocation. Phosphorylated by PRKDC.
Polyubiquitinated. Polyubiquitination of ABL1 leads to degradation.
Isoform IB is myristoylated on Gly-2.

DISEASE:
Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.

Gene ID:
25

Database links:
Entrez Gene: 25 Human
Entrez Gene: 11350 Mouse
Omim: 189980 Human
SwissProt: P00519 Human
SwissProt: P00520 Mouse
Unigene: 431048 Human
Unigene: 1318 Mouse
Unigene: 474779 Mouse

phospho-c-ABL1+2 (Tyr393+439),***酸化非受体酪氨酸激酶c-Abl抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

非受体酪氨酸激酶c-Abl广泛表达于各组织细胞中,c-Abl是非受体酪氨酸激酶Src家族的一个成员。在生理状态下,它可以定位于多个亚细胞结构(如细胞核、细胞质、线粒体等)中并呈现不同功能。经研究认为,细胞核内的c-Abl在细胞凋亡调控以及DNA损伤修复过程中起重要作用,而胞质中的c-Abl则与细胞黏附、细胞分化及氧化应激有关联,该蛋白主要用于细胞凋亡的研究。