Gemin 2,脊髓性肌萎缩症蛋白SMA抗体
英文名称: Anti-Gemin 2 antibody
型号:null    抗体货号: HZ-11562R
价格:请致电:010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

Gemin 2,脊髓性肌萎缩症蛋白SMA抗体

产品编号HZ-11562R
英文名称Gemin 2
中文名称脊髓性肌萎缩症蛋白SMA抗体
别 名SMA; Gemin2; Component of gems 2; Gem (nuclear organelle) associated protein 2; Gem associated protein 2; GEMI2_HUMAN; Gemin-2; gemin2; SIP 1; SIP-1; SIP1; SIP1 delta; SIP1-delta ; SMN interacting protein 1; SMN interacting protein 1 delta; SMN-interacting protein 1; Survival interacting protein 1; Survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, Rabbit,
Gemin 2,脊髓性肌萎缩症蛋白SMA抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Gemin 2 (101-200aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Gemin 2,脊髓性肌萎缩症蛋白SMA抗体PubMedPubMed
产品介绍background:
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011].

Function:
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.

Subunit:
Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN5.

Subcellular Location:
Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.

Similarity:
Belongs to the gemin-2 family.

Database links:
Entrez Gene: 8487 Human
Entrez Gene: 66603 Mouse
Entrez Gene: 84404 Rat
Omim: 602595 Human
SwissProt: O14893 Human
SwissProt: Q9CQQ4 Mouse
SwissProt: Q9QZP1 Rat
Unigene: 652307 Human
Unigene: 35353 Mouse
Unigene: 34143 Rat

Gemin 2,脊髓性肌萎缩症蛋白SMA抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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