DPF1/Neuro D4,神经D4抗体

产品编号HZ-19215R
英文名称DPF1/Neuro D4
中文名称神经D4抗体
别 名BAF45B; BRG1-associated factor 45B; D4; D4 zinc and double PHD fingers family 1; DPF1; DPF1_HUMAN; NEUD4; Neuro d4 homolog; Zinc and double PHD fingers family 1; Zinc finger protein neuro-d4.
说 明 书0.1ml 0.2ml
研究领域神经生物学 细胞周期蛋白 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应
DPF1/Neuro D4,神经D4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DPF1/Neuro D4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DPF1/Neuro D4,神经D4抗体PubMedPubMed
产品介绍background:
DPF1 is a 353 amino acid protein that contains two PHD-type zinc fingers and belongs to the requiem/DPF family. Localized to both the nucleus and the cytoplasm, DPF1 is thought to play an important role in the regulation of neuronal cell survival. Specifically, DPF1 may function as a neurospecific transcription factor that binds DNA and participates in cell cycle progression. Human and rat DPF1 share 93% sequence identity, suggesting a conserved role between species. Multiple isoforms of DPF1 exist due to alternative splicing events.

Function:
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Belongs to the requiem/DPF family.
Contains 2 PHD-type zinc fingers.

Gene ID:
8193

Database links:
Entrez Gene: 8193 Human
Entrez Gene: 29861 Mouse
Entrez Gene: 50545 Rat
SwissProt: Q92782 Human
SwissProt: Q9QX66 Mouse
SwissProt: P56163 Rat
Unigene: 631576 Human
Unigene: 101885 Mouse
Unigene: 453136 Mouse
Unigene: 453137 Mouse
Unigene: 42906 Rat

DPF1/Neuro D4,神经D4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.