Anti - Cytokeratin 20
英文名称： Anti - Cytokeratin 20
型号:null    抗体货号： DB 119-0.5
价格:请致电：010-57128832,18610462672
品牌: 美国/中国    产品商标: db biotech

上海信裕生物科技有限公司是一家集研发、生产、销售、服务于一体的国际领先生物高新技术企业，专营基因、蛋白、抗体、Elisa试剂盒、细胞生物学，分子生物学等高质量生物产品。抗体纯化/标记/免疫检测：免疫分析检测是一项应用广泛的技术，利用抗原和抗体的特异性反应进行检测的一种手段，广泛用于医学病理学、免疫组织化学、分子生物学、生物制药等领域的分析研究与技术测定。制备高特异性、高效价的抗体是实验免疫学技术的基础，抗体质量的高低将直接影响试验的成败。抗体纯化能降低非特异性本底，抗体标记能通过标记物的增强放大效应提高检测灵敏度，采用ELISA、WB、IP、IHC等不同免疫分析技术检测各种样品中特定的目的蛋白。

ved from human DCUN1D3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DCUN1D3,DCN1样蛋白3抗体PubMedPubMed
产品介绍background:
Dcun1D3 is a 304 amino acid protein that contains one Dcun1 domain. The Dcun1 domain is an approximately 190 residue module that is thought to have the features of a basic helix-loop-helix leucine zipper domain, a domain commonly found in transcription factors. It has been suggested that Dcun1D3 may be involved in cell cycle progression and cell growth. The gene that encodes Dcun1D3 maps to human chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Chromosome 16 houses the CREBBP gene that encodes a critical CREB binding protein that is responsible for the Rubinstein-Taybi syndrome, a rare disorder characterized by mental retardation and predisposition to tumor growth and white blood cell neoplasias.

Subcellular Location:
Contains 1 DCUN1 domain.

Gene ID:
123879

Database links:
Entrez Gene: 123879 Human
Entrez Gene: 504926 Cow
Entrez Gene: 233805 Mouse
Entrez Gene: 309035 Rat
SwissProt: Q5E9V1 Cow
SwissProt: Q8IWE4 Human
SwissProt: Q8K0V2 Mouse
SwissProt: Q4V8B2 Rat
Unigene: 101007 Human
Unigene: 31539 Mouse
Unigene: 211721 Rat

DCUN1D3,DCN1样蛋白3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

tern blot:  
Gαs activation assay. Purified Gαs proteins were loaded as a control (lanes 1) or immunoprecipitated after treated with GDP (lane 2) or GTPγS (lane 3). Immunoprecipitation was done with the anti-active Gαs monoclonal antibody (Cat. No. 26906). Immunoblot was with an anti- Gαs monoclonal antibody (Cat. No. 26006).

 

Publications:
1.  Glucocorticoid acts on a putative G protein-coupled receptor to rapidly regulate the activity of NMDA receptors in hippocampal neurons
    Am J Physiol Endocrinol Metab. 2012 Apr 1;302(7):E747-58
2.  CRH activation of different signaling pathways results in differential calcium signaling in human pregnant myometrium before and during labor
    J Clin Endocrinol Metab. 2012 Oct;97(10):E1851-61
3.  Estrogenic action on arterial smooth muscle: permissive for maintenance of CRHR2 expression
    Endocrinology. 2012 Apr;153(4):1915-24
4.  Corticotropin-releasing hormone stimulates mitotic kinesin-like protein 1 expression via a PLC/PKC-dependent signaling pathway in hippocampal neurons
    Mol Cell Endocrinol. 2012 Oct 15;362(1-2):157-64
5.   Rapid actions of xenoestrogens disrupt normal estrogenic signaling
     Steroids Volume 81, March 2014, Pages 36–42
6.   Neuronal NF1/RAS regulation of cyclic AMP requires atypical PKC activation
     Hum. Mol. Genet. (2014)