FGF9,碱性成纤维细胞生长因子9抗体

产品编号HZ-5906R
英文名称FGF9
中文名称碱性成纤维细胞生长因子9抗体
别 名FGF 9; FGF-9; FGF9; FGF9_HUMAN; Fibroblast growth factor 9; GAF; Glia Activating Factor; Glia-activating factor; HBFG 9; HBFG9; HBGF-9; Heparin-binding growth factor 9; MGC119914; MGC119915.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 免疫学 神经生物学 生长因子和***
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog,
FGF9,碱性成纤维细胞生长因子9抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FGF9
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FGF9,碱性成纤维细胞生长因子9抗体PubMedPubMed
产品介绍background:
May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Function:
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Subunit:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

Subcellular Location:
Secreted.

Tissue Specificity:
Glial cells.

FGF9,碱性成纤维细胞生长因子9抗体Post-translational modifications:
Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.

DISEASE:
Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3) [MIM:612961]. Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness.

Similarity:
Belongs to the heparin-binding growth factors family.

Gene ID:
2254

Database links:
Entrez Gene: 378917 Chicken
Entrez Gene: 2254 Human
Entrez Gene: 14180 Mouse
Entrez Gene: 396717 Pig
Entrez Gene: 25444 Rat
Omim: 600921 Human
SwissProt: P31371 Human
SwissProt: P54130 Mouse
SwissProt: Q95L12 Pig
SwissProt: P36364 Rat
Unigene: 111 Human
Unigene: 8846 Mouse
Unigene: 25174 Rat

FGF9,碱性成纤维细胞生长因子9抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.