C1orf84,1号染色体开放阅读框84抗体

产品编号HZ-15077R
英文名称C1orf84
中文名称1号染色体开放阅读框84抗体
别 名Chromosome 1 open reading frame 84; Hypothetical protein LOC149469; Uncharacterized protein C1orf84; SZT2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
C1orf84,1号染色体开放阅读框84抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量378kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C1orf84
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
C1orf84,1号染色体开放阅读框84抗体PubMedPubMed
产品介绍background:
SZT2 (seizure threshold 2 homolog (mouse)), also known as SZT2A or SZT2B, is a 3,432 amino acid peroxisomal protein that plays a role in resistance to oxidative stress. Predominantly expressed in the parietal and frontal cortex, as well as in dorsal root ganglia of the brain, SZT2 is implicated in superoxide dismutase activity and the neuroprotection in peroxisomes. Existing as four alternatively spliced isoforms, SZT2 is thought to enhance epileptogenesis and is encoded by a gene that maps to human chromosome 1p34.2. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.

Function:
Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and confer low seizure threshold (By similarity).

Subcellular Location:
Peroxisome (By similarity).

Tissue Specificity:
Expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia.

C1orf84,1号染色体开放阅读框84抗体Database links:
UniProtKB/Swiss-Prot: Q5T011.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.