FBXO11,F-box蛋白家族FBXO11抗体

产品编号HZ-8490R
英文名称FBXO11
中文名称F-box蛋白家族FBXO11抗体
别 名F box protein 11; F-box only protein 11; FBX11; FBX11_HUMAN; Fbxo11; PRMT9; VIT-1; VIT1; Vitiligo associated protein VIT 1; Vitiligo-associated protein 1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
FBXO11,F-box蛋白家族FBXO11抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from hu FBXO11
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FBXO11,F-box蛋白家族FBXO11抗体PubMedPubMed
产品介绍background:
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBXO11 (F-box only protein 11), also known as VIT1 (Vitiligo-associated protein 1), is a 927 amino acid nuclear protein that contains one UBR-type zinc finger, one F-box domain and 19 PbH1 repeats. Involved in protein ubiquitination, FBXO11 functions as a substrate recognition component of the SCF complex and is thought to bind to and inhibit the transcriptional activity of p53. Reduced expression of FBXO11 is associated with vitiligo, a disease characterized by progressive skin depigmentation. Multiple isoforms of FBXO11 exist due to alternative splicing events.

Tissue Specificity:
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.

FBXO11,F-box蛋白家族FBXO11抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.