CDKN2B/p15 INK4b,细胞周期蛋白依赖性激酶抑制剂2B抗体

产品编号HZ-4269R
英文名称CDKN2B/p15 INK4b
中文名称细胞周期蛋白依赖性激酶抑制剂2B抗体
别 名CDK inhibitory protein; CDK4B Inhibitor; CDKN2B; Cyclin dependent kinase 4 inhibitor B; Cyclin Dependent Kinase Inhibitor 2B; Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4; Cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS 2; MTS2; Multiple Tumor Supressor 2; p14 CDK inhibitor; p14 INK4b; P15; p15 CDK inhibitor; p15 inhibits CDK4; p15 INK4b; P15(INK4B); p15INK4B; TP 15; TP15.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导 干细胞 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
CDKN2B/p15 INK4b,细胞周期蛋白依赖性激酶抑制剂2B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量15kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CDKN2B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CDKN2B/p15 INK4b,细胞周期蛋白依赖性激酶抑制剂2B抗体PubMedPubMed
产品介绍background:
p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers.

Function:
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Subunit:
Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6.

Subcellular Location:
Cytoplasm. Note=Also found in the nucleus.

Tissue Specificity:
Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.

Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats.

Gene ID:
1030

Database links:
Entrez Gene: 1030 Human
Entrez Gene: 12579 Mouse
Entrez Gene: 25164 Rat
Omim: 600431 Human
SwissProt: P42772 Human
SwissProt: P55271 Mouse
SwissProt: P55272 Rat
Unigene: 72901 Human
Unigene: 423094 Mouse
Unigene: 105626 Rat

CDKN2B/p15 INK4b,细胞周期蛋白依赖性激酶抑制剂2B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.