phospho-delta 1 Catenin (Tyr280),***酸化δ连环蛋白抗体

产品编号HZ-14262R
英文名称phospho-delta 1 Catenin (Tyr280)
中文名称***酸化δ连环蛋白抗体
别 名delta 1 Catenin (phospho Y280); p-delta 1 Catenin (phospho Y280); Cadherin associated Src substrate; Cadherin-associated Src substrate; CAS; Catenin (cadherin associated protein) delta 1; Catenin delta 1; Catenin delta-1; CTND1_HUMAN; CTNND 1; CTNND; CTNND1; KIAA0384; p120; P120 CAS; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN.
说 明 书0.1ml
产品类型***酸化抗体
研究领域细胞生物 信号转导 干细胞 转录调节因子 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
phospho-delta 1 Catenin (Tyr280),***酸化δ连环蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量106kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human delta 1 Catenin around the phosphorylation site of Tyr280
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-delta 1 Catenin (Tyr280),***酸化δ连环蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

Function:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.

Tissue Specificity:
Expressed in vascular endothelium.

Post-translational modifications:
Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.

Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.

Gene ID:
1500

Database links:
Entrez Gene: 1500 Human
Entrez Gene: 12388 Mouse
Entrez Gene: 311163 Rat
Omim: 601045 Human
SwissProt: O60716 Human
SwissProt: P30999 Mouse
Unigene: 166011 Human
Unigene: 35738 Mouse
Unigene: 9435 Rat

phospho-delta 1 Catenin (Tyr280),***酸化δ连环蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.