DPP2,溶酶体丝氨酸蛋白酶DPP2抗体

产品编号HZ-6045R
英文名称DPP2
中文名称溶酶体丝氨酸蛋白酶DPP2抗体
别 名Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; DPP II; DPP2; DPP7; DPPII; QPP; Quiescent cell proline dipeptidase.
说 明 书0.1ml 0.2ml
研究领域细胞生物 激酶和***酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
DPP2,溶酶体丝氨酸蛋白酶DPP2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
细胞定位细胞浆 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DPP2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DPP2,溶酶体丝氨酸蛋白酶DPP2抗体PubMedPubMed
产品介绍background:
DPP2 is a serine protease found most abundantly in the lysosome. There is also a non-lysosomal membrane-associated form of DPP2 reported in the rat brain (DPP-II-M), and a soluble form (DPP-II-S). First discovered as an enzyme involved in the terminal steps of protein degradation, and later as an enzyme involved in cell growth and quiescence, DPP2 cleaves N-terminal dipeptides and tripeptides from proteins. DPP2 has a preference for proline in the P1 position, and processes the tripeptides generated by DPP1 (which is unable to cleave if proline is in the P1 position). Some tumor cell lines express elevated DPP2 levels, and serum levels of DPP2 are elevated in some cancer patients, making DPP2 a potential tumor marker. DPP2 levels have been also been reported to be elevated in the cerebral spinal fluid from Parkinson’s patients.

Function:
Plays an important role in the degradation of some oligopeptides.

Subunit:
Homodimer.

Subcellular Location:
Lysosome. Cytoplasmic vesicle. Secreted.

Tissue Specificity:
Detected in seminal plasma (at protein level).

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the peptidase S28 family.

Gene ID:
29952

DPP2,溶酶体丝氨酸蛋白酶DPP2抗体Database links:
Entrez Gene: 29952 Human
Entrez Gene: 83768 Mouse
Entrez Gene: 83799 Rat
Omim: 610537 Human
SwissProt: Q9UHL4 Human
SwissProt: Q9ET22 Mouse
SwissProt: Q9EPB1 Rat
Unigene: 37916 Human
Unigene: 3363 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.