phospho-NIFK (Thr234),***酸化NIFK抗体

产品编号HZ-7938R
英文名称phospho-NIFK (Thr234)
中文名称***酸化NIFK抗体
别 名NIFK (phospho T234); NIFK (phospho Thr234); p-NIFK(T234); p-NIFK(Thr234); hNIFK; MKI67 FHA Domain Interacting Nucleolar Phosphoprotein; MKI67IP; NOPP34; Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI 67; pKi67; MK67I_HUMAN.
说 明 书0.1ml
产品类型***酸化抗体
研究领域肿瘤 信号转导 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep,
phospho-NIFK (Thr234),***酸化NIFK抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human NIFK/MKI67IP around the phosphorylation site of Thr234
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-NIFK (Thr234),***酸化NIFK抗体PubMedPubMed
产品介绍background:
This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009].

Subunit:
Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis.

Subcellular Location:
Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.

Post-translational modifications:
Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding.

Similarity:
Contains 1 RRM (RNA recognition motif) domain.

Gene ID:
84365

Database links:
Entrez Gene: 84365 Human
Entrez Gene: 67949 Mouse
Omim: 611970 Human
SwissProt: Q8TB66 Human
SwissProt: Q9BYG3 Human
SwissProt: Q91VE6 Mouse
Unigene: 367842 Human
Unigene: 280311 Mouse

phospho-NIFK (Thr234),***酸化NIFK抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.