EAAT1,胶质细胞谷氨酸运载蛋白1抗体

产品编号HZ-1003R
英文名称EAAT1
中文名称胶质细胞谷氨酸运载蛋白1抗体
别 名EA6; EAAT1; Excitatory amino acid transporter 1; FLJ25094; GLAST; GLAST1; Glial high affinity glutamate transporter; High affinity neuronal glutamate transporter; Slc1a3; Sodium dependent glutamate/aspartate transporter; EAA1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
EAAT1,胶质细胞谷氨酸运载蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EAAT1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EAAT1,胶质细胞谷氨酸运载蛋白1抗体PubMedPubMed
产品介绍background:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. [SUBCELLULAR LOCATION] Membrane; Multi-pass membrane protein. [TISSUE SPECIFICITY] Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. [SIMILARITY] Belongs to the sodium: dicarboxylate (SDF) symporter(TC 2.A.23) family.

Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Subunit:
Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily.

Subcellular Location:
Membrane.

Tissue Specificity:
Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.

Post-translational modifications:
Glycosylated.

EAAT1,胶质细胞谷氨酸运载蛋白1抗体DISEASE:
Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.

Similarity:
Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily.

Gene ID:
6507

Database links:
Entrez Gene: 6507 Human
Entrez Gene: 20512 Mouse
Entrez Gene: 29483 Rat
Omim: 600111 Human
SwissProt: P43003 Human
SwissProt: P56564 Mouse
SwissProt: P24942 Rat
Unigene: 481918 Human
Unigene: 204834 Mouse
Unigene: 34134 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

EAAT-1主要用于神经胶质细胞的损伤及退变方面的研究.